Role of the Extracellular Matrix in Muscle Injuries: Histoarchitectural Considerations for Muscle Injuries

In recent years, different classifications of muscle injury have been proposed based on topographic location within the bone-tendon-muscle chain.1,3,4,7 Furthermore, because the degree and level of extracellular matrix (ECM) involvement might vary greatly, we propose to include histoarchitectural considerations in the gross anatomic description of muscle injuries.