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Neonatal hypoxia and pulmonary vasospasm: Response to tolazoline
- Source :
- The Journal of Pediatrics. 89:617-621
- Publication Year :
- 1976
- Publisher :
- Elsevier BV, 1976.
-
Abstract
- Forty-six neonates with hypoxemia were treated with tolazoline, a pulmonary vasodilator, within the first two days of life. Eight of ten (80%) infants without apparent lung disease responded with a mean increase in PaO2 of 116 torr within one hour of beginning tolazoline infusions. One of the responding infants and two nonresponders died. Thirty-six additional infants with a variety of pulmonary disorders had severe hypoxemia which was refractory to mechanical ventilation. Twenty-one (58%) responded with a mean increase in PaO2 of 130 torr within one hour after beginning tolazoline and 13 (62%) of these survived. Fifteen patients had little or no improvement in PaO2 following tolazoline and only three (20%) of these infants survived. Responders could not be distinguished from nonresponders by clinical or laboratory features prior to therapy with tolazoline. Fourteen infants experienced complications possibly related to tolazoline.
- Subjects :
- Lung Diseases
Male
Pulmonary Circulation
medicine.medical_treatment
Infant, Newborn, Diseases
Hypoxemia
Severe hypoxemia
medicine
Humans
Hypoxia
Tolazoline
Mechanical ventilation
business.industry
Infant, Newborn
Vasospasm
Hypoxia (medical)
medicine.disease
Neonatal hypoxia
respiratory tract diseases
Anesthesia
Pediatrics, Perinatology and Child Health
Female
medicine.symptom
Gastrointestinal Hemorrhage
business
medicine.drug
Pulmonary disorders
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....fa369e2f22943ec413850b7d59ee51d2