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Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review
- Source :
- Harsløf, T, Rolighed, L & Rejnmark, L 2019, ' Huge variations in definition and reported incidence of postsurgical hypoparathyroidism : a systematic review ', Endocrine, vol. 64, no. 1, pp. 176-183 . https://doi.org/10.1007/s12020-019-01858-4
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- PURPOSE: The reported incidence of post surgical hypoparathyroidism (HypoPT) varies greatly. Previous research suggests that the definition of HypoPT is not consistent in the literature. We therefore conducted a systematic review to investigate how HypoPT is defined and whether this definition, as well as the selected threshold for hypocalcemia affects the incidence. METHODS: Using a predefined search string we identified all articles in PubMed reporting on the incidence of postsurgical HypoPT from 1st January 2010 to January 2017. RESULTS: We identified 89 articles that employed 20 different definition of HypoPT. The incidence of HypoPT varied from 0.0% to 20.2%. The definitions were not associated with incidence of HypoPT. Use of prophylactic post-operative calcium supplements, however decreased the risk of HypoPT (p = 0.03), and there was a trend towards a lower risk of HypoPT when using a definition of hypocalcemia below lower limit of the reference range (p = 0.09). CONCLUSION: The large number of definitions of HypoPT, as well as the huge variation in incidence point to a problem suggests that the awareness of HypoPT should be raised. Use of prophylactic post-operative calcium supplements may decrease risk of HypoPT. This, however, may be due to reverse causality as awareness of the risk of HypoPT may promote the use of calcium supplementation.
- Subjects :
- Pediatrics
medicine.medical_specialty
Hypoparathyroidism
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Reference range
Lower risk
Lower limit
Post-surgical hypoparathyroidism
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Endocrinology
Calcium supplementation
medicine
Permanent
Humans
Reverse causality
business.industry
Incidence
Incidence (epidemiology)
Definition
medicine.disease
030220 oncology & carcinogenesis
Thyroidectomy
business
Subjects
Details
- ISSN :
- 15590100 and 1355008X
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....fa30b0153f761bd6bd5d9dd1af2fe1fb