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NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary
- Source :
- REPRODUCTION. 138:131-140
- Publication Year :
- 2009
- Publisher :
- Bioscientifica, 2009.
-
Abstract
- Recent studies have demonstrated that neurotrophins (NTs) and their NTRK tyrosine kinase receptors, thought to be exclusively required for the development of the nervous system, are also involved in controlling ovarian development. Here, we show that primordial follicle formation is decreased in the absence of nerve growth factor (NGF) or its receptor NTRK1, and in the absence of NTRK2, the receptor for neurotrophin-4 (NTF4) and brain-derived neurotrophic factor (BDNF). This deficiency is not due to premature oocyte loss, because the ovaries ofNtrk1−/−andNtrk2−/−mice do not show an increased rate of oocyte death antedating the initiation of folliculogenesis. Moreover, exposure of NGF-deficient ovaries to NGF rescues the defect in follicular assembly, if NTRK1 receptors are present, suggesting that the absence of NTs causes a delay, and not an irretrievable loss, of follicle formation. Both the number of secondary follicles and FSH receptor (FSHR) expression are diminished inNtrk1- andNtrk2-null ovaries, but not in ovaries lacking the common NT receptor NGFR. Transient exposure of wild-type ovaries to NTF4 increasesFshrgene expression and enhances the ability of the ovary to respond to FSH with formation of cyclin D2, a cell cycle protein mediating the proliferative actions of FSH in the ovary. These results indicate that both NTRK1 and NTRK2 receptors are necessary for the timely assembly of primordial follicles and for sustaining early follicular development. They also suggest that a mechanism by which NTRK2 receptors facilitate subsequent follicle development is by inducing the formation of functional FSHR.
- Subjects :
- endocrine system
Embryology
medicine.medical_specialty
Mice, 129 Strain
Time Factors
Apoptosis
Ovary
Biology
Article
Tissue Culture Techniques
Mice
Endocrinology
Ovarian Follicle
Internal medicine
Nerve Growth Factor
medicine
Animals
Cyclin D2
Low-affinity nerve growth factor receptor
Nerve Growth Factors
Receptor, trkA
Ovarian follicle
Receptor
Mice, Knockout
Membrane Glycoproteins
Obstetrics and Gynecology
Cell Biology
Protein-Tyrosine Kinases
Cell biology
Mice, Inbred C57BL
medicine.anatomical_structure
nervous system
Animals, Newborn
Reproductive Medicine
Oocytes
biology.protein
Receptors, FSH
Female
Folliculogenesis
Follicle Stimulating Hormone
Signal transduction
Follicle-stimulating hormone receptor
Signal Transduction
Neurotrophin
Subjects
Details
- ISSN :
- 17417899 and 14701626
- Volume :
- 138
- Database :
- OpenAIRE
- Journal :
- REPRODUCTION
- Accession number :
- edsair.doi.dedup.....fa1dd21d49c64df0c06d9ce69fa3cc70