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Prognostic relevance of AgNORs in tumor pathology
- Source :
- Micron. 31:133-141
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- The importance of the analysis of the silver-stained nucleolar organizer regions (AgNORs) for prognostic purposes in tumor pathology has been reviewed. Current available data from the literature demonstrate that the evaluation of the quantity of interphase AgNORs is an independent prognostic factor in several types of human tumors. Results of our investigations indicate that AgNORs are the most powerful variable predicting survival in patients with pharyngeal carcinoma, multiple myeloma, male breast and prostate carcinoma. The combination of AgNOR counts and histologic pattern allows the stratification of patients with multiple myeloma, pharyngeal and prostate carcinoma into low- and high-risk groups, which could benefit from different therapy. Moreover, AgNOR analysis predicts response to treatment in adult patients with acute myelogenous leukemia, and appears as an independent prognostic factor in a prospective study on renal cell carcinoma. Therefore, AgNOR analysis is a really important prognostic factor for several human neoplasias. The experimental and theoretical justifications for AgNORs as a prognostic factor are also reviewed, in particular the strict correlation between AgNOR quantity and tumor cell doubling time. Lastly, the lack of prognostic significance of AgNOR analysis in some circumstances is critically discussed.
- Subjects :
- Adult
Male
Oncology
Silver Staining
medicine.medical_specialty
Pathology
General Physics and Astronomy
tumours
Myelogenous
Structural Biology
Renal cell carcinoma
Neoplasms
Internal medicine
Nucleolus Organizer Region
medicine
Humans
Doubling time
General Materials Science
Prospective cohort study
Multiple myeloma
AgNOR
prognosis
business.industry
Nuclear Proteins
Cell Biology
medicine.disease
Tumor Pathology
Leukemia
Female
Nucleolus organizer region
business
Subjects
Details
- ISSN :
- 09684328
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Micron
- Accession number :
- edsair.doi.dedup.....fa1239573498aded669056f723f808c7
- Full Text :
- https://doi.org/10.1016/s0968-4328(99)00070-0