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Short-term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France
- Source :
- Clinical and Experimental Allergy, Clinical and Experimental Allergy, 2018, 48 (7), pp.837-845. ⟨10.1111/cea.13160⟩, Clinical and Experimental Allergy, Wiley, 2018, 48 (7), pp.837-845. ⟨10.1111/cea.13160⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Acknowledgement of partial funding by Astra-Zeneca, Boehringer Ingelheim, ALK-Abello. The researchers are totally independent of the funder; BackgroundOutdoor moulds are classically associated with exacerbations of asthma.ObjectiveThe aim of this paper was to examine nasal allergy morbidity by studying the short-term relationship between mould spore exposure and daily sales of reimbursable anti-allergic treatment in central France.MethodsThe relationship between daily changes in mould concentrations and daily sales obtained from the national healthcare database was analysed with generalized additive models, taking into account confounding factors such as air pollution, weather conditions, pollen counts, and days of the week.ResultsDuring the study, the average total yearly number of treated people was around 10000 over approximately 230000 surveyed. The relative risk (95% CI confidence interval) of sales of oral antihistamines with topical treatment associated with an interquartile increase in mould concentration was significant for Cladosporium 1.079 [1.019-1.142] and Aspergillus-Penicillium (Asp-Pen) 1.051 [1.021-1.082] in the whole population. When the influence of age and sex was considered, the relationship was significant only in male children aged 0-12years and those aged between 13 and 49years for Cladosporium: 1.256 [1.081-1.460] and 1.151 [1.063-1.245], respectively. The relationship was also significant for Asp-Pen: 1.038 [1.003-1.075] for those aged between 13 and 49years and 1.056 [1.007-1.108] for adults over 50years of age.ConclusionThe association between prescribed daily sales of oral antihistamines with topical treatment sales is associated with temporal changes to Cladosporium and Aspergillus-Penicillium in the whole population. When the influence of age and sex was considered, these two moulds contributed to prescribed medication sales only in the male general population.
- Subjects :
- Male
0301 basic medicine
mould
Names of the days of the week
outdoor
0302 clinical medicine
Risk Factors
Interquartile range
Anti-Allergic Agents
Epidemiology
Immunology and Allergy
Medicine
Child
education.field_of_study
biology
food and beverages
Middle Aged
Spores, Fungal
Child, Preschool
Pollen
Female
epidemiology
France
Cladosporium
Adult
medicine.medical_specialty
Adolescent
Immunology
Population
Histamine Antagonists
Drug Prescriptions
Risk Assessment
Young Adult
03 medical and health sciences
Hypersensitivity
Humans
education
Asthma
allergic rhinitis
drug prescription
business.industry
Infant, Newborn
Infant
Environmental Exposure
Allergens
biology.organism_classification
medicine.disease
Confidence interval
030104 developmental biology
030228 respiratory system
Relative risk
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 09547894 and 13652222
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Allergy, Clinical and Experimental Allergy, 2018, 48 (7), pp.837-845. ⟨10.1111/cea.13160⟩, Clinical and Experimental Allergy, Wiley, 2018, 48 (7), pp.837-845. ⟨10.1111/cea.13160⟩
- Accession number :
- edsair.doi.dedup.....fa1121e0f227bfef248af5075797bd34