Back to Search
Start Over
Use of preoperative parathyroid fine-needle aspiration and parathormone assay in the primary hyperparathyroidism with concomitant thyroid nodules
- Source :
- The American Journal of Surgery. 193:665-671
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Although the sensitivity of imaging studies is high in solitary parathyroid adenomas, negative results are inevitable. The aims of this prospective clinical study are to evaluate the impact of the presence of thyroid disease on the sensitivity and positive predictive value (PPV) of ultrasonography (US), sestamibi (MIBI), and parathyroid fine needle aspiration and parathormone assay (PTH-FNA).The patients were divided into 4 groups according to preoperative imaging studies: group A (n = 62) with US, group B (n = 62) with MIBI, group C (n = 62) with US + MIBI, and group D (n = 62) with PTH-FNA. These 4 groups were subdivided according to the presence (group 1) or absence (group 2) of thyroid nodule.In the overall patients, the sensitivity and PPV of PTH-FNA to localize parathyroid adenoma was higher compared with US, MIBI, and US + MIBI (100% and 100% versus 96% and 91% versus 92% and 87% versus 95% and 94%, respectively, P.05). The sensitivity and PPV of US, MIBI, and US + MIBI in the patients without thyroid nodule was higher compared with the patients with thyroid nodule (100% and 100%, 100% and 96%, 100% and 100% versus 93% and 84%, 85% and 80%, 96% and 86%, respectively, P.05). The sensitivity and PPV of the PTH-FNA was 100% in the patients with and without a thyroid nodule.PTH-FNA can be performed safely for the confirmation of parathyroid adenoma localized by preoperative imaging studies. In patients with a concomitant thyroid nodule, PTH-FNA was more accurate to detect the parathyroid adenoma than the other imaging studies.
- Subjects :
- Adult
Male
Parathyroidectomy
Thyroid nodules
medicine.medical_specialty
medicine.medical_treatment
Biopsy, Fine-Needle
Sensitivity and Specificity
Parathyroid Glands
Preoperative Care
medicine
Humans
Prospective Studies
Thyroid Nodule
Aged
Parathyroid adenoma
Hyperparathyroidism
medicine.diagnostic_test
business.industry
Thyroid disease
Thyroid
General Medicine
Middle Aged
Hyperparathyroidism, Primary
medicine.disease
Fine-needle aspiration
medicine.anatomical_structure
Parathyroid Hormone
Female
Immunoradiometric Assay
Surgery
Radiology
business
Nuclear medicine
Biomarkers
hormones, hormone substitutes, and hormone antagonists
Primary hyperparathyroidism
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029610
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgery
- Accession number :
- edsair.doi.dedup.....f9f1a6e008c89ae5eef6ecf30c604956