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Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study
- Source :
- Diabetes & Metabolism, 39(1), 42-49. MASSON EDITEUR, Diabetes and Metabolism, 39(1), 42-49. Elsevier Masson, Bot, M, Pouwer, F, De Jonge, P, Nolan, J J, Mari, A, Højlund, K, Golay, A, Balkau, B & Dekker, J M 2013, ' Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study ', Diabetes & Metabolism, vol. 39, no. 1, pp. 42-49 . https://doi.org/10.1016/j.diabet.2012.09.005, Diabetes & metabolism (Online) (2013). doi:10.1016/j.diabet.2012.09.005, info:cnr-pdr/source/autori:Bot, M.;Pouwer, F.;De Jonge, P.;Nolan, J.J.;Mari, A.;Hojlund, K.;Golay, A.;Balkau, B.;Dekker, J.M./titolo:Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study/doi:10.1016%2Fj.diabet.2012.09.005/rivista:Diabetes & metabolism (Online)/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume, Bot, M, Pouwer, F, de Jonge, P, Nolan, J J, Mari, A, Hojlund, K, Golay, A, Balkau, B & Dekker, J M 2013, ' Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study ', Diabetes and Metabolism, vol. 39, no. 1, pp. 42-49 . https://doi.org/10.1016/j.diabet.2012.09.005, Diabetes & Metabolism, 39(1), 42-49. Elsevier Masson, Diabetes & Metabolism, Vol. 39, No 1 (2013) pp. 42-49
- Publication Year :
- 2013
-
Abstract
- Aim. This study explored the association of depressive symptoms with indices of insulin sensitivity and insulin secretion in a cohort of non-diabetic men and women aged 30 to 64 years.Methods. The study population was derived from the 3-year follow-up of the Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) study. Presence of significant depressive symptoms was defined as a Center for Epidemiologic Studies Depression Scale (CES-D) score >= 16. Standard oral glucose tolerance tests were performed. Insulin sensitivity was assessed with the oral glucose insulin sensitivity (OGIS) index. Insulin secretion was estimated using three model-based parameters of insulin secretion (beta-cell glucose sensitivity, the potentiation factor ratio, and beta-cell rate sensitivity).Results. A total of 162 out of 1027 participants (16%) had significant depressive symptoms. Having significant depressive symptoms was not related to either OGIS [standardized beta (beta) -0.033; P=0.24] or beta-cell glucose sensitivity ([3 0.007; P=0.82). Significant depressive symptoms were related to decreased beta-cell rate sensitivity (odds ratio for significant depressive symptoms of the lowest vs. highest quartile of beta-cell rate sensitivity was 2.04; P =0.01). Also, significant depressive symptoms were associated with a statistically significant decrease in the potentiation factor ratio in unadjusted models, but not in the fully adjusted model.Conclusion. Depressive symptoms were not related to insulin sensitivity and tended to be weakly associated to some parameters of insulin secretion in non-diabetic individuals. Prospective studies are needed to study the temporal association between depression and insulin secretion. (C) 2012 Elsevier Masson SAS. All rights reserved.
- Subjects :
- Blood Glucose
Male
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Body Mass Index
Cohort Studies
Endocrinology
Surveys and Questionnaires
YOUNG-ADULTS
Odds Ratio
Medicine
Insulin
Prospective cohort study
POPULATION
ASSOCIATIONS
education.field_of_study
Glucose tolerance test
medicine.diagnostic_test
Depression
Insulin secretion
Diabetes
WOMEN
General Medicine
Center for Epidemiologic Studies Depression Scale
Middle Aged
Insulin sensitivity
Europe
Cardiovascular Diseases
Female
HEALTH
Adult
medicine.medical_specialty
Population
TYPE-2 DIABETES-MELLITUS
Insulin resistance
BETA-CELL FUNCTION
Diabetes mellitus
Internal medicine
Internal Medicine
Humans
education
METAANALYSIS
ddc:613
business.industry
Odds ratio
Glucose Tolerance Test
medicine.disease
ORAL GLUCOSE-TOLERANCE
Insulin Resistance
business
RESISTANCE
Follow-Up Studies
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 39
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diabetes and Metabolism
- Accession number :
- edsair.doi.dedup.....f9def7e28e10e8425efbd20e63ba116e