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Evaluation of drugs for treatment of prion infections of the central nervous system
- Source :
- Journal of General Virology. 89:594-597
- Publication Year :
- 2008
- Publisher :
- Microbiology Society, 2008.
-
Abstract
- Prion diseases are fatal and at present there are neither cures nor therapies available to delay disease onset or progression in humans. Inspired in part by therapeutic approaches in the fields of Alzheimer's disease and amyotrophic lateral sclerosis, we tested five different drugs, which are known to efficiently pass through the blood–brain barrier, in a murine prion model. Groups of intracerebrally prion-challenged mice were treated with the drugs curcumin, dapsone, ibuprofen, memantine and minocycline. Treatment with antibiotics dapsone and minocycline had no therapeutic benefit. Ibuprofen-treated mice showed severe adverse effects, which prevented assessment of therapeutic efficacy. Mice treated with low- but not high-dose curcumin and mice treated with memantine survived infections significantly longer than untreated controls (P
- Subjects :
- Drug
Curcumin
medicine.drug_class
media_common.quotation_subject
Antibiotics
Ibuprofen
Minocycline
Biology
Pharmacology
Dapsone
Prion Diseases
Mice
Central Nervous System Diseases
Memantine
Virology
medicine
Animals
Amyotrophic lateral sclerosis
Adverse effect
media_common
Therapeutic effect
medicine.disease
Evaluation Studies as Topic
Immunology
medicine.drug
Subjects
Details
- ISSN :
- 14652099 and 00221317
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology
- Accession number :
- edsair.doi.dedup.....f9d9e88ea3fd7decde0cca1a59224146