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Interleukin-10 family members: Biology and role in the bone and joint diseases

Authors :
Shenghui Ni
Fengping Shan
Jin Geng
Source :
International immunopharmacology. 108
Publication Year :
2022

Abstract

Interleukin (IL)-10 family cytokines include IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29. These cytokines play crucial regulatory roles in various biological reactions and diseases. In recent years, several studies have shown that the IL-10 family plays a vital role in bone and joint diseases, including bone metabolic diseases, fractures, osteoarthritis, rheumatoid arthritis, and bone tumors. Herein, the recent progress on the regulatory role of IL-10 family of cytokines in the occurrence and development of bone and joint diseases has been summarized. This review will provide novel directions for immunotherapy of bone and joint diseases.

Details

ISSN :
18781705
Volume :
108
Database :
OpenAIRE
Journal :
International immunopharmacology
Accession number :
edsair.doi.dedup.....f9d74a5ecd04b4b797d27b40d5859b3a