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Depressant-like effects of parthenolide in a rodent behavioural antidepressant test battery
- Source :
- Journal of Pharmacy and Pharmacology. 60:1643-1650
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- The anti-serotonergic effects of parthenolide (PTL) demonstrated in platelets inspired the present psychopharmacological investigation, which employs a battery of rodent behavioural assays of depression. In mice, PTL (0.5-2 mg kg−1) exhibited dose-dependent depressant-like effects in a forced swim test and a tail suspension test, without affecting the baseline locomotor status. The doses (1 and 2 mg kg−1) that induced depressant-like effects were found to significantly reduce 5-hydroxytrypto-phan-induced head twitch response. Interaction studies revealed that the depressant-like effects of PTL (1 mg kg−1) were reversed more efficiently by serotonergic antidepressants (venlafaxine, escitalopram, citalopram, fluoxetine) than by others (desipramine, bupropion) tested. Chronic treatment of PTL (1 and 2 mg kg−1) augmented the hyper-emotionality of olfactory bulbectomized rats, when compared with sham rats, as observed in modified open field, elevated plus maze and social interaction paradigms. This study depicts the severe depressogenic potential of PTL (in its pure form) plausibly mediated by platelet/neuronal hypo-serotonergic effects.
- Subjects :
- Male
Elevated plus maze
medicine.medical_specialty
Pharmaceutical Science
Venlafaxine
Motor Activity
Pharmacology
Citalopram
Open field
Head-twitch response
Mice
Desipramine
Internal medicine
medicine
Animals
Rats, Wistar
Maze Learning
Social Behavior
Swimming
Behavior, Animal
Dose-Response Relationship, Drug
Depression
business.industry
Olfactory Bulb
Antidepressive Agents
Tail suspension test
Rats
Disease Models, Animal
Endocrinology
Exploratory Behavior
Serotonin Antagonists
business
Sesquiterpenes
medicine.drug
Behavioural despair test
Subjects
Details
- ISSN :
- 20427158 and 00223573
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi.dedup.....f9cd28d41d4ec01d4cb4ffd9954a4e5b