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Bimodal control of stimulated food intake by the endocannabinoid system
- Source :
- Nature Neuroscience, Nature Neuroscience, Nature Publishing Group, 2010, 13 (3), pp.281-283. ⟨10.1038/nn.2494⟩, Nature Neuroscience; Vol 13
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB(1) receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
- Subjects :
- medicine.medical_specialty
Food intake
Time Factors
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Glutamic Acid
Mice, Transgenic
Biology
Receptors, N-Methyl-D-Aspartate
Synaptic Transmission
03 medical and health sciences
Glutamatergic
Eating
Mice
0302 clinical medicine
Receptor, Cannabinoid, CB1
Internal medicine
medicine
Animals
RNA, Messenger
gamma-Aminobutyric Acid
030304 developmental biology
Mice, Knockout
Neurons
0303 health sciences
General Neuroscience
digestive, oral, and skin physiology
Body Weight
Brain
Neural Inhibition
Fasting
Receptors, GABA-A
SYSTÈME ENDOCANNABINOÏDE
Endocannabinoid system
Corpus Striatum
3. Good health
Mice, Inbred C57BL
Endocrinology
nervous system
Forebrain
GABAergic
lipids (amino acids, peptides, and proteins)
Cannabinoid
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 10976256 and 15461726
- Database :
- OpenAIRE
- Journal :
- Nature Neuroscience, Nature Neuroscience, Nature Publishing Group, 2010, 13 (3), pp.281-283. ⟨10.1038/nn.2494⟩, Nature Neuroscience; Vol 13
- Accession number :
- edsair.doi.dedup.....f9b564323a878ae30e3c0c53e4503391
- Full Text :
- https://doi.org/10.1038/nn.2494⟩