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Formulation and antitumorigenic activities of nanoencapsulated nifetepimine: A promising approach in treating triple negative breast carcinoma

Authors :
Rajni Khan
Mrinal K. Ghosh
Suman Bhandary
Bhaswati Banerjee
Aparajita Ghosh
Parimal C. Sen
Aparna Laskar
Nirmalendu Das
Arijit Bhowmik
Arijit Chakraborty
Atanu Biswas
Sandip Dolui
Salil Putatunda
Source :
Nanomedicine: Nanotechnology, Biology and Medicine. 12:1973-1985
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

Triple negative breast cancer (TNBC) is one of the most common invasive malignancies among women, associated with poor prognosis. Standard chemotherapy targets all dividing cells, resulting in dose-limiting toxicities. In this study, we demonstrated a strategy of encapsulating a hydrophobic synthetic compound, nifetepimine, having anticancer properties, in poly (lactic-co-glycolic acid) nanoparticles to increase selectivity of drug to cancerous cells with minimum toxicity towards normal cells. Nanoencapsulated nifetepimine (30-100nm) having loading and encapsulation efficiency of 7.45% and 75% respectively, was successfully internalized inside TNBC cells upon sustained release resulting in apoptosis. An in vivo bio-distribution study indicated that nanonifetepimine selectively accumulated into breast tumor sites of mice, primarily due to prolonged blood circulation time and binding of nifetepimine to epidermal growth factor receptor that remains overexpressed in most of the TNBC tumors. Moreover, we observed significant reduction in breast tumor volume with improved survival implying high tumor targetability of nanonifetepimine.

Details

ISSN :
15499634
Volume :
12
Database :
OpenAIRE
Journal :
Nanomedicine: Nanotechnology, Biology and Medicine
Accession number :
edsair.doi.dedup.....f9b47b08fcc5d7446e9d6b5473dcbadb
Full Text :
https://doi.org/10.1016/j.nano.2016.04.011