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Formulation and antitumorigenic activities of nanoencapsulated nifetepimine: A promising approach in treating triple negative breast carcinoma
- Source :
- Nanomedicine: Nanotechnology, Biology and Medicine. 12:1973-1985
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Triple negative breast cancer (TNBC) is one of the most common invasive malignancies among women, associated with poor prognosis. Standard chemotherapy targets all dividing cells, resulting in dose-limiting toxicities. In this study, we demonstrated a strategy of encapsulating a hydrophobic synthetic compound, nifetepimine, having anticancer properties, in poly (lactic-co-glycolic acid) nanoparticles to increase selectivity of drug to cancerous cells with minimum toxicity towards normal cells. Nanoencapsulated nifetepimine (30-100nm) having loading and encapsulation efficiency of 7.45% and 75% respectively, was successfully internalized inside TNBC cells upon sustained release resulting in apoptosis. An in vivo bio-distribution study indicated that nanonifetepimine selectively accumulated into breast tumor sites of mice, primarily due to prolonged blood circulation time and binding of nifetepimine to epidermal growth factor receptor that remains overexpressed in most of the TNBC tumors. Moreover, we observed significant reduction in breast tumor volume with improved survival implying high tumor targetability of nanonifetepimine.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Antineoplastic Agents
Apoptosis
Triple Negative Breast Neoplasms
Bioengineering
Pyrimidinones
Mice
03 medical and health sciences
0302 clinical medicine
Epidermal growth factor
In vivo
Cell Line, Tumor
medicine
Animals
Humans
Tissue Distribution
General Materials Science
Breast
Epidermal growth factor receptor
Triple-negative breast cancer
Chemotherapy
biology
Chemistry
Molecular biology
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
biology.protein
Nanoparticles
Molecular Medicine
Female
Triple-Negative Breast Carcinoma
Subjects
Details
- ISSN :
- 15499634
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nanomedicine: Nanotechnology, Biology and Medicine
- Accession number :
- edsair.doi.dedup.....f9b47b08fcc5d7446e9d6b5473dcbadb
- Full Text :
- https://doi.org/10.1016/j.nano.2016.04.011