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Synthesis and activity of a novel class of tribasic macrocyclic antibiotics: the triamilides
- Source :
- Bioorganicmedicinal chemistry letters. 12(19)
- Publication Year :
- 2002
-
Abstract
- The stereoselective synthesis of two novel series of tribasic macrocyclic antibiotics with potent in vitro activity against Pasteurella multocida and Escherichia coli strains of bacteria is described. The in vitro activity can be significantly influenced by the nature of the substituents on the C-4" aminoalcohol, with the stereochemistry of the C-4" alcohol playing a less critical role. The effect of substitution and stereochemistry on the in vivo activity in a murine model of respiratory infection is also described.
- Subjects :
- Models, Molecular
Pasteurella multocida
Stereochemistry
Clinical Biochemistry
Pasteurella Infections
Molecular Conformation
Pharmaceutical Science
Microbial Sensitivity Tests
medicine.disease_cause
Biochemistry
Chemical synthesis
Mice
In vivo
Drug Discovery
medicine
Escherichia coli
Animals
Molecular Biology
Escherichia coli Infections
Antibacterial agent
biology
Bacteria
Chemistry
Organic Chemistry
Respiratory infection
Biological activity
Stereoisomerism
Bacterial Infections
biology.organism_classification
Enterobacteriaceae
Anti-Bacterial Agents
Molecular Medicine
Indicators and Reagents
Macrolides
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....f9acdd3797d17393d46849abe8bdbba4