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The functional impact of nuclear reorganization in cellular senescence
- Source :
- Briefings in Functional Genomics
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Cellular senescence is the irreversible cell cycle arrest in response to DNA damage. Because senescent cells accumulate with age and contribute to chronic inflammation, they are promising therapeutic targets for healthspan extension. The senescent phenotype can vary depending on cell type and on the specific insults that induce senescence. This variability is also reflected in the extensive remodeling of the genome organization within the nucleus of senescent cells. Here, we give an overview of the nuclear changes that occur in different forms of senescence, including changes to chromatin state and composition and to the three-dimensional organization of the genome, as well as alterations to the nuclear envelope and to the accessibility of repetitive genomic regions. Many of these changes are shared across all forms of senescence, implicating nuclear organization as a fundamental driver of the senescent state and of how senescent cells interact with the surrounding tissue.
- Subjects :
- Cell Nucleus
AcademicSubjects/SCI01140
Review Paper
0303 health sciences
nuclear organization
aging
epigenome
Cellular senescence
Functional impact
Genomics
General Medicine
Biology
Biochemistry
Cell biology
03 medical and health sciences
0302 clinical medicine
Genetics
cellular senescence
chromatin
Molecular Biology
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 20412657 and 20412649
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Briefings in Functional Genomics
- Accession number :
- edsair.doi.dedup.....f9ab4c4adc7a38c9d76d1a82ee4d32e5