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Effects of combining azilsartan medoxomil with amlodipine in patients with stage 2 hypertension
- Source :
- Blood Pressure Monitoring
- Publication Year :
- 2014
-
Abstract
- Objective The aim of the study was to measure the effects on blood pressure (BP) of the angiotensin receptor blocker azilsartan medoxomil, in 40 and 80 mg doses, combined with 5 mg of the calcium channel blocker amlodipine and to compare these effects with placebo plus amlodipine 5 mg. Methods This was a randomized, controlled, double-blind study of 6 weeks’ duration in 566 patients with stage 2 hypertension. The primary endpoint was 24-h systolic BP by ambulatory monitoring. Results The mean age of the participants was 58 years; men and women were equally represented, and baseline 24-h BP (153–154/93 mmHg) and clinic BP (165–166/94–95 mmHg) were similar across the three treatment groups. After 6 weeks, 24-h BP decreased by 25/15 mmHg in both the azilsartan medoxomil/amlodipine 40/5 and 80/5 mg groups. These reductions were each greater than the 14/8 mmHg decrease with placebo plus amlodipine 5 mg (P≤0.001 for both comparisons). All treatments were well tolerated, and adverse events did not increase with the azilsartan medoxomil doses. Edema or fluid retention was less common in both combination groups (2.6 and 2.7%) than with placebo plus amlodipine (7.6%). Conclusion Coadministration of azilsartan medoxomil with amlodipine was well tolerated and led to meaningful additional BP reductions compared with placebo plus amlodipine.
- Subjects :
- Male
Angiotensin receptor
medicine.medical_specialty
medicine.drug_class
Blood Pressure
Calcium channel blocker
Assessment and Diagnosis
Pharmacology
amlodipine
Placebo
Double-Blind Method
Internal medicine
Internal Medicine
medicine
Stage 2 hypertension
Humans
In patient
Amlodipine
Azilsartan Medoxomil
Antihypertensive Agents
Aged
Advanced and Specialized Nursing
Oxadiazoles
angiotensin II receptor blockers
business.industry
azilsartan medoxomil
General Medicine
Blood Pressure Monitoring, Ambulatory
Middle Aged
Calcium Channel Blockers
Clinical Trial
ambulatory blood pressure monitoring
Endocrinology
Blood pressure
Hypertension
Benzimidazoles
Drug Therapy, Combination
Female
Cardiology and Cardiovascular Medicine
business
Angiotensin II Type 1 Receptor Blockers
medicine.drug
Subjects
Details
- ISSN :
- 14735725
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Blood pressure monitoring
- Accession number :
- edsair.doi.dedup.....f9897671869d1b53e518561fa42a2d11