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Impact of International Normalized Ratio and Activated Clotting Time on Unfractionated Heparin Dosing During Ablation of Atrial Fibrillation
- Source :
- Circulation: Arrhythmia and Electrophysiology. 6:491-496
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Background— For ablation of atrial fibrillation, it is unclear how baseline international normalized ratio (INR) affects the dosing of unfractionated heparin (UFH). Methods and Results— A retrospective review of 170 consecutive patients undergoing atrial fibrillation ablation with baseline activated clotting time (ACT) and INR values was performed. Patients were grouped according to INR P P =0.0001). Baseline INR, ACT, and weight were predictors of the UFH dosage to achieve an ACT ≥300 seconds. An equation derived to achieve an ACT ≥300 seconds after a single bolus of UFH met this end point in 160 of 168 patients (95%). Conclusions— Baseline INR and ACT, in addition to weight, are the only predictors of UFH dosage needed to achieve an ACT ≥300 seconds. A derived equation predicted the UFH dosage to achieve an ACT ≥300 seconds.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Ablation of atrial fibrillation
Activated clotting time
Catheter ablation
Risk Assessment
Cohort Studies
Electrocardiography
Bolus (medicine)
Physiology (medical)
Internal medicine
Atrial Fibrillation
medicine
Humans
International Normalized Ratio
Dosing
Blood Coagulation
Aged
Retrospective Studies
Intraoperative Care
Dose-Response Relationship, Drug
medicine.diagnostic_test
Heparin
business.industry
Warfarin
Atrial fibrillation
Middle Aged
medicine.disease
Surgery
Treatment Outcome
Multivariate Analysis
Catheter Ablation
Cardiology
Regression Analysis
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 19413084 and 19413149
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Circulation: Arrhythmia and Electrophysiology
- Accession number :
- edsair.doi.dedup.....f97990863dfe8f7e93c9fef1456f6aa7
- Full Text :
- https://doi.org/10.1161/circep.113.979088