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Impact of International Normalized Ratio and Activated Clotting Time on Unfractionated Heparin Dosing During Ablation of Atrial Fibrillation

Authors :
Charles J. Love
Steven J. Kalbfleisch
Ismail Hamam
Zhenguo Liu
Troy E. Rhodes
John D. Hummel
Emile G. Daoud
Marshall W. Winner
Jaret Tyler
Mahmoud Houmsse
Raul Weiss
Molly Sachdev
Ralph Augostini
Shane Tsai
Jianying Zhang
Source :
Circulation: Arrhythmia and Electrophysiology. 6:491-496
Publication Year :
2013
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2013.

Abstract

Background— For ablation of atrial fibrillation, it is unclear how baseline international normalized ratio (INR) affects the dosing of unfractionated heparin (UFH). Methods and Results— A retrospective review of 170 consecutive patients undergoing atrial fibrillation ablation with baseline activated clotting time (ACT) and INR values was performed. Patients were grouped according to INR P P =0.0001). Baseline INR, ACT, and weight were predictors of the UFH dosage to achieve an ACT ≥300 seconds. An equation derived to achieve an ACT ≥300 seconds after a single bolus of UFH met this end point in 160 of 168 patients (95%). Conclusions— Baseline INR and ACT, in addition to weight, are the only predictors of UFH dosage needed to achieve an ACT ≥300 seconds. A derived equation predicted the UFH dosage to achieve an ACT ≥300 seconds.

Details

ISSN :
19413084 and 19413149
Volume :
6
Database :
OpenAIRE
Journal :
Circulation: Arrhythmia and Electrophysiology
Accession number :
edsair.doi.dedup.....f97990863dfe8f7e93c9fef1456f6aa7
Full Text :
https://doi.org/10.1161/circep.113.979088