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GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
- Publication Year :
- 2007
- Publisher :
- The University of North Carolina at Chapel Hill University Libraries, 2007.
-
Abstract
- Background: Polymorphisms in glutathione-S-transferase ( GST ), N-acetyltransferase ( NAT ) 1 , and CYP1A1 genes have been suggested as susceptibility factors for esophageal and gastric adenocarcinomas, but have not been consistently linked to elevated risks. In a population-based case–control study, we examined risks in relation to polymorphisms of the following genes: GSTP1 ; GSTM1 ; GSTT1 ; NAT1 ; and CYP1A1 . Methods: Histologically confirmed incident cases, ages 30–79, were identified in three US locations. Population controls from the same catchment areas were frequency matched to expected age and sex distributions of esophageal and gastric cardia adenocarcinomas. DNA was extracted from buffy coat for PCR-based assays, with interpretable genotyping results obtained from 209 controls, 67 esophageal adenocarcinomas, 60 gastric cardia adenocarcinomas, and 56 noncardia gastric adenocarcinomas. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated among whites, adjusting for age, sex, and study center. Results: In all histologic subgroups, ORs were somewhat elevated for the GSTP1 Val/Val genotype (versus Ile/Ile ), although 95% CIs included 1.00. The respective ORs for esophageal, cardia, and other gastric adenocarcinomas were 1.73 (0.75–4.02), 1.46 (0.57–3.73), and 1.22 (0.48–3.09). No consistent patterns of elevated risk were associated with the null GSTM1 or GSTT1 genotypes, one or two copies of NAT1*10 or *11 alleles, or CYP1A1 Val/Val or Ile/Val genotypes (versus Ile/Ile ). Conclusions: Additional research in larger samples is needed to further assess polymorphisms and their interactions with epidemiologic risk factors, particularly for esophageal adenocarcinoma, which has been increasing markedly in incidence.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Pathology
Esophageal Neoplasms
Arylamine N-Acetyltransferase
Population
Biology
Adenocarcinoma
Gastroenterology
Polymerase Chain Reaction
Article
GSTP1
Risk Factors
Stomach Neoplasms
Internal medicine
Genotype
medicine
Cytochrome P-450 CYP1A1
Odds Ratio
Humans
Genetic Predisposition to Disease
Gastrointestinal cancer
education
Genotyping
Alleles
Aged
Glutathione Transferase
education.field_of_study
Polymorphism, Genetic
Case-control study
Odds ratio
Middle Aged
medicine.disease
digestive system diseases
United States
Isoenzymes
Oncology
Glutathione S-Transferase pi
Case-Control Studies
Female
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f9422dd64f4e4d434279d3be2028d861
- Full Text :
- https://doi.org/10.17615/zbzh-fb55