Back to Search
Start Over
Changes in Measles Serostatus Among HIV-Infected Zambian Children Initiating Antiretroviral Therapy Before and After the 2010 Measles Outbreak and Supplemental Immunization Activities
- Source :
- The Journal of Infectious Diseases. 208:1747-1755
- Publication Year :
- 2013
- Publisher :
- Oxford University Press (OUP), 2013.
-
Abstract
- Background. In 2010, Zambia had a large measles outbreak, providing an opportunity to measure changes in measles serostatus following highly active antiretroviral therapy (HAART), exposure to measles virus, and revaccination among children infected with human immunodeficiency virus (HIV). Methods. A prospective cohort study of 169 HIV-infected Zambian children aged 9–60 months with a history of measles vaccination was conducted to characterize the effects of HAART and revaccination on measles immunoglobulin G (IgG) serostatus by enzyme immunoassay. Results. Prior to the measles outbreak, only 23% of HIV-infected children were measles IgG seropositive at HAART initiation. After adjusting for 6-month changes in baseline age and 5% changes in nadir CD4+ T-cell percentage, HAART was not associated with measles IgG seroconversion. However, 18 of 19 children seroconverted after revaccination. Eight children seroconverted during the outbreak without revaccination and were likely exposed to wild-type measles virus, but none were reported to have had clinical measles. Conclusions. Immune reconstitution after HAART initiation did not restore protective levels of measles IgG antibodies, but almost all children developed protective antibody levels after revaccination. Some previously vaccinated HIV-infected children had serological evidence of exposure to wild-type measles virus without a reported history of measles.
- Subjects :
- Male
Measles Vaccine
Population
Immunization, Secondary
Zambia
HIV Infections
Antibodies, Viral
Measles
Disease Outbreaks
Cohort Studies
Measles virus
Major Articles and Brief Reports
immune system diseases
Seroepidemiologic Studies
Antiretroviral Therapy, Highly Active
Humans
Immunology and Allergy
Medicine
Prospective Studies
Seroconversion
Child
education
education.field_of_study
biology
business.industry
Vaccination
Infant
virus diseases
Viral Load
medicine.disease
biology.organism_classification
Virology
Infectious Diseases
Immunization
Child, Preschool
Immunoglobulin G
Immunology
HIV-1
Female
Measles vaccine
business
Serostatus
Follow-Up Studies
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 208
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....f93bf43b24c73b0e531d3b09b475d0ad
- Full Text :
- https://doi.org/10.1093/infdis/jit404