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Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants
- Source :
- International Journal of Oral and Maxillofacial Surgery. 44:1302-1308
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- This study evaluated the influence of type 2 diabetes mellitus (T2DM) on the gene expression of bone-related factors in alveolar bone tissue from sites designated to receive dental implants. Bone biopsies were harvested from sites of planned implants for 19 systemically healthy patients and 35 patients with T2DM (17 with better-controlled T2DM (glycated haemoglobin (HbA1c) levels ≤8%) and 18 with poorly controlled T2DM (HbA1c levels >8%)). The mRNA levels of tumour necrosis factor alpha, transforming growth factor beta, receptor activator of the nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), runt-related transcription factor 2, alkaline phosphatase, bone sialoprotein (BSP), type I collagen (COL-I), and osteocalcin were evaluated by quantitative real-time polymerase chain reaction. T2DM up-regulates RANKL levels and the ratio of RANKL/OPG, whereas it down-regulates COL-I and BSP expression (P
- Subjects :
- Adult
Male
musculoskeletal diseases
Bone sialoprotein
medicine.medical_specialty
endocrine system diseases
Biopsy
Gene Expression
Core Binding Factor Alpha 1 Subunit
Real-Time Polymerase Chain Reaction
Collagen Type I
Osteoprotegerin
Transforming Growth Factor beta
Internal medicine
Alveolar Process
Humans
Integrin-Binding Sialoprotein
Medicine
RNA, Messenger
Dental alveolus
Aged
Dental Implants
biology
Tumor Necrosis Factor-alpha
business.industry
RANK Ligand
nutritional and metabolic diseases
Middle Aged
Alkaline Phosphatase
Endocrinology
Real-time polymerase chain reaction
Diabetes Mellitus, Type 2
Otorhinolaryngology
RANKL
Osteocalcin
biology.protein
Alkaline phosphatase
Female
Surgery
Oral Surgery
business
Biomarkers
Type I collagen
Subjects
Details
- ISSN :
- 09015027
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- International Journal of Oral and Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....f937f0f49c22d87154d513505eb3a144