Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI

Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted to life expectancy. From 2002 to 2013, we reviewed 224 patients with LMUM selected by liver MRI. A nomogram was developed based on a Cox model. The predictive performance of the model was assessed according to the C-statistic, Kaplan&ndash
Meier curve, and calibration plots. The median follow-up was 49.2 months (range, 0.6&ndash
70.9). The survival rates at 6, 12, and 24 months were 0.88 (0.95 CI [0.84&ndash
0.93]), 0.68 (0.95 CI [0.62&ndash
0.75]), and 0.26 (0.95 CI [0.21&ndash
0.33]), respectively. The four factors selected for the nomogram with a worse prognosis were: A disease-free interval between the UM and LMUM groups of less than 6 months (HR = 3.39
0.95 CI [1.90&ndash
6.05]), more than 10 LMUM (HR = 3.95
0.95 CI [1.97&ndash
4.43]), a maximum LMUM of more than 1200 mm2 (HR = 2.47
0.95 CI [1.53&ndash
3.98]), and a lactate dehydrogenase (LDH) value greater than 1.5 (HR = 3.72
0.95 CI [2.30&ndash
6.00]). The model achieved relatively good discrimination and calibration (C-statistic 0.71). This nomogram could be useful for decision-making and risk stratification for therapeutic options.