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The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans
- Source :
- Atherosclerosis, 132, 251-254, Atherosclerosis, 132(2), 251-254. Elsevier Ireland Ltd, Atherosclerosis 132 (1997), van Tol, A, Urgert, R, de Jong-Caesar, R, van Gent, T, Scheek, L M, de Roos, B & Katan, M B 1997, ' The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans ', Atherosclerosis, vol. 132, no. 2, pp. 251-254 . https://doi.org/10.1016/S0021-9150(97)00099-3, Atherosclerosis, 251-254. Elsevier Ireland Ltd, ISSUE=132;STARTPAGE=251;ENDPAGE=254;ISSN=0021-9150;TITLE=Atherosclerosis
- Publication Year :
- 1997
-
Abstract
- Cafestol and kahweol-diterpenes present in unfiltered coffee-strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown. We determined whether the coffee diterpenes may affect lipoprotein metabolism via effects on lipid transfer proteins and lecithin:cholesterol acyltransferase in a randomized, double-blind cross-over study with 10 healthy male volunteers. Either cafestol (61-64 mg/day) or a mixture of cafestol (60 mg/day) and kahweol (48-54 mg/day) was given for 28 days. Serum activity levels of cholesterylester transfer protein, phospholipid transfer protein and lecithin:cholesterol acyltransferase were measured using exogenous substrate assays. Relative to baseline values, cafestol raised the mean (+/- S.D.) activity of cholesterylester transfer protein by 18 +/- 12% and of phospholipid transfer protein by 21 +/- 14% (both P0.001). Relative to cafestol alone, kahweol had no significant additional effects Lecithin:cholesterol acyltransferase activity was reduced by 11 +/- 12% by cafestol plus kahweol (P = 0.02). It is concluded that the effects of coffee diterpenes on plasma lipoproteins may be connected with changes in serum activity levels of lipid transfer proteins.
- Subjects :
- Adult
Male
medicine.medical_specialty
Very low-density lipoprotein
Sterol O-acyltransferase
LCAT
Cafestol
Kahweol
Lipoproteins, VLDL
Coffee
chemistry.chemical_compound
Internal medicine
Phospholipid transfer protein
Cholesterylester transfer protein
CETP
medicine
Humans
VLAG
Human Nutrition & Health
biology
Cholesterol
Humane Voeding & Gezondheid
Lipoproteins, LDL
Endocrinology
chemistry
PLTP
biology.protein
lipids (amino acids, peptides, and proteins)
Lipid transfer proteins
Diterpenes
Carrier Proteins
Lipoproteins, HDL
Cardiology and Cardiovascular Medicine
Plant lipid transfer proteins
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00219150
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis, 132, 251-254, Atherosclerosis, 132(2), 251-254. Elsevier Ireland Ltd, Atherosclerosis 132 (1997), van Tol, A, Urgert, R, de Jong-Caesar, R, van Gent, T, Scheek, L M, de Roos, B & Katan, M B 1997, ' The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans ', Atherosclerosis, vol. 132, no. 2, pp. 251-254 . https://doi.org/10.1016/S0021-9150(97)00099-3, Atherosclerosis, 251-254. Elsevier Ireland Ltd, ISSUE=132;STARTPAGE=251;ENDPAGE=254;ISSN=0021-9150;TITLE=Atherosclerosis
- Accession number :
- edsair.doi.dedup.....f9209d3e15449820fda43264de49f8b6