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Clinical utility and prospective of TMS–EEG
Clinical utility and prospective of TMS–EEG
- Source :
- Clinical Neurophysiology. 130:802-844
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) has emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the assessment of several cortical properties such as excitability and connectivity. Over the past decade, this technique has been applied to various clinical populations, enabling the characterization and development of potential TMS-EEG predictors and markers of treatments and of the pathophysiology of brain disorders. The objective of this article is to present a comprehensive review of studies that have used TMS-EEG in clinical populations and to discuss potential clinical applications. To provide a technical and theoretical framework, we first give an overview of TMS-EEG methodology and discuss the current state of knowledge regarding the use of TMS-EEG to assess excitability, inhibition, plasticity and connectivity following neuromodulatory techniques in the healthy brain. We then review the insights afforded by TMS-EEG into the pathophysiology and predictors of treatment response in psychiatric and neurological conditions, before presenting recommendations for how to address some of the salient challenges faced in clinical TMS-EEG research. Finally, we conclude by presenting future directions in line with the tremendous potential of TMS-EEG as a clinical tool.
- Subjects :
- Treatment response
genetic structures
medicine.medical_treatment
Electroencephalography
behavioral disciplines and activities
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Humans
Medicine
0501 psychology and cognitive sciences
Evoked Potentials
medicine.diagnostic_test
business.industry
musculoskeletal, neural, and ocular physiology
05 social sciences
Brain
Transcranial Magnetic Stimulation
Sensory Systems
Biomarker (cell)
Transcranial magnetic stimulation
nervous system
Neurology
Neurology (clinical)
Nerve Net
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....f903914a8c510ff2c157132e5e73649b
- Full Text :
- https://doi.org/10.1016/j.clinph.2019.01.001