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Clinical utility and prospective of TMS–EEG

Clinical utility and prospective of TMS–EEG

Authors :
Reza Zomorrodi
Daniel M. Blumberger
Pantelis Lioumis
Vincenzo Di Lazzaro
Fabio Ferrarelli
Faranak Farzan
Zafiris J. Daskalakis
Tarek K. Rajji
Ulf Ziemann
Silvia Casarotto
Maria Concetta Pellicciari
Vasilios K. Kimiskidis
Alvaro Pascual-Leone
Isabella Premoli
Gregor Thut
Paul B. Fitzgerald
Nigel C. Rogasch
Sara Tremblay
Dimitris Kugiumtzis
Robert Chen
Jeanette Hui
Risto J. Ilmoniemi
Source :
Clinical Neurophysiology. 130:802-844
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

Concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) has emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the assessment of several cortical properties such as excitability and connectivity. Over the past decade, this technique has been applied to various clinical populations, enabling the characterization and development of potential TMS-EEG predictors and markers of treatments and of the pathophysiology of brain disorders. The objective of this article is to present a comprehensive review of studies that have used TMS-EEG in clinical populations and to discuss potential clinical applications. To provide a technical and theoretical framework, we first give an overview of TMS-EEG methodology and discuss the current state of knowledge regarding the use of TMS-EEG to assess excitability, inhibition, plasticity and connectivity following neuromodulatory techniques in the healthy brain. We then review the insights afforded by TMS-EEG into the pathophysiology and predictors of treatment response in psychiatric and neurological conditions, before presenting recommendations for how to address some of the salient challenges faced in clinical TMS-EEG research. Finally, we conclude by presenting future directions in line with the tremendous potential of TMS-EEG as a clinical tool.

Details

ISSN :
13882457
Volume :
130
Database :
OpenAIRE
Journal :
Clinical Neurophysiology
Accession number :
edsair.doi.dedup.....f903914a8c510ff2c157132e5e73649b
Full Text :
https://doi.org/10.1016/j.clinph.2019.01.001