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DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology
- Source :
- Journal of Epidemiology
- Publication Year :
- 2012
- Publisher :
- Japan Epidemiological Association, 2012.
-
Abstract
- Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay.
- Subjects :
- Epidemiology
Review Article
chemistry.chemical_compound
Risk Factors
Neoplasms
Biomarkers, Tumor
Humans
Medicine
Prospective cohort study
plasma
blood-based biomarker
Randomized Controlled Trials as Topic
Molecular Epidemiology
DNA methylation
Molecular epidemiology
business.industry
Cancer
General Medicine
peripheral blood
Prognosis
medicine.disease
chemistry
Immunology
Leukocytes, Mononuclear
Nucleic acid
Cancer research
Biomarker (medicine)
Cancer biomarkers
business
serum
leukocyte
DNA
Subjects
Details
- ISSN :
- 13499092 and 09175040
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....f8fea66d38e4e267a2c5283e56656db9