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The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes
- Source :
- Reproductive BioMedicine Online. 43:738-746
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Research question Can the adipocytokine milieu of the follicular niche improve the ability to predict treatment outcomes in infertile patients? Design Follicular fluid samples from overweight patients were analysed and compared with samples from matched normal-weight patients. Concentrations of adiponectin, chemerin, C-reactive protein, interleukin-6 (IL-6), IL-10, IL-18, insulin, leptin, prolactin, resistin, tumour necrosis factor alpha (TNF-α) and bone morphogenetic protein-15 (BMP-15) were assessed by multiple magnetic bead immunoassay (MMBI) and enzyme-linked immunosorbent assay and correlated with fertility treatment outcomes. Results Analysis of samples from 22 overweight and 22 normal-weight patients demonstrated that TNF-α can predict oocyte maturation rate. When stratified by body mass index (BMI), IL-10 emerges as a better predictor of oocyte maturation in normal-weight patients. Prolactin was a negative predictor for fertilization rate in the full cohort, and this prediction power was lost upon stratification. No adipocytokines were predictive of blastulation rate, and only age remained predictive. BMP-15 was a strong predictor of high-quality blastulation in the full cohort, more so in the normal-weight population. Conclusions The adipocytokine milieu of the follicular fluid provides a snapshot of the growing oocyte's environment and can help predict fertility treatment outcomes, fine-tuning understanding of the dysregulation caused by increasing BMI. Inflammatory cytokines can predict oocyte maturation; prolactin, oocyte competence; and BMP-15, high-quality blastulation. Further analysis of these findings with a larger sample size and assessing individual oocytes will help shed more light on the clinical significance of these findings.
- Subjects :
- Adult
Population
Adipokine
Body Mass Index
Andrology
Young Adult
Adipokines
Follicular phase
Humans
Medicine
Chemerin
Obesity
education
Retrospective Studies
education.field_of_study
biology
business.industry
Obstetrics and Gynecology
Follicular fluid
Follicular Fluid
In Vitro Oocyte Maturation Techniques
Reproductive Medicine
Cohort
biology.protein
Female
Resistin
business
Infertility, Female
Body mass index
Developmental Biology
Subjects
Details
- ISSN :
- 14726483
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Reproductive BioMedicine Online
- Accession number :
- edsair.doi.dedup.....f8f0ed29cddb8d41020fcae92c239d31