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Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain
- Publication Year :
- 2022
-
Abstract
- Neurodegenerative diseases are characterized by the abnormal accumulation of aggregated proteins in the brain. Using in vivo pulse isotope labeling, we screened the proteome for changes in protein turnover and abundance in multiple mouse models of neurodegeneration. These data suggest that the disease state of pathologically affected tissue is characterized by a proteome-wide increase in protein turnover and repair. In contrast, in healthy wild-type mice, aging in the mammalian brain is associated with a global slowdown in protein turnover.
- Subjects :
- Mammals
Proteomics
TRANSGENIC MICE
Aging
Proteome
PROTEINS
DATABASE
3112 Neurosciences
Brain
Mice, Transgenic
QUANTIFICATION
DEGRADATION
Biochemistry
Analytical Chemistry
MECHANISMS
Disease Models, Animal
Mice
MOUSE MODELS
Alzheimer Disease
DISEASES
Animals
TURNOVER
ALZHEIMERS
Molecular Biology
219 Environmental biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f8ea7dc04ce65e99e1f8cb116d222e1e