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Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression
- Source :
- Pharmacology Biochemistry and Behavior; Vol 97
- Publication Year :
- 2011
- Publisher :
- PERGAMON-ELSEVIER SCIENCE LTD, 2011.
-
Abstract
- The neurochemical basis of depression focuses on alterations in the monoaminergic and amino acid neurotransmitter systems. Moreover, decreases in serum levels of the neurotrophin brain-derived neurotrophic factor (BDNF) have led to the more recent neurotrophic hypothesis of depression. Chronic stress is one of the major predisposing factors to developing the disorder and thus we investigated the impact of chronic restraint stress on the levels of several neurotransmitters and their metabolites in a genetic animal model of depression, the Wistar Kyoto (WKY) rat. Behavioural analysis of WKY rats indicated both a depressive and anxiety-like phenotype compared to their Sprague Dawley (SD) controls. WKY animals showed similar stress-induced decreases in hippocampal GABA, noradrenaline and dopamine as their SD counterparts while exhibiting a divergent decrease in 5-HT, 5-HIAA and DOPAC. WKY rats also showed a stress-dependent increase in GABA concentrations in the amygdala compared to the SD animals. Moreover, WKY but not SD rats had a chronic stress-induced decrease in serum BDNF levels. Together these data show that there are specific strain-dependent changes in neurotransmitter and neurotrophin levels in response to chronic stress which may predispose WKY animals to a depressive-like phenotype.
- Subjects :
- Male
medicine.medical_specialty
Clinical Biochemistry
Enzyme-Linked Immunosorbent Assay
Toxicology
Hippocampus
Rats, Inbred WKY
Biochemistry
Rats, Sprague-Dawley
Immobilization
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Neurochemical
Species Specificity
Stress, Physiological
Dopamine
Neurotrophic factors
Internal medicine
Monoaminergic
medicine
Animals
Chronic stress
Neurotransmitter
Biological Psychiatry
030304 developmental biology
Pharmacology
Brain-derived neurotrophic factor
Neurotransmitter Agents
0303 health sciences
Behavior, Animal
Brain-Derived Neurotrophic Factor
Amygdala
Rats
Endocrinology
nervous system
chemistry
Amino acid neurotransmitter
Corticosterone
Psychology
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00913057
- Volume :
- 97
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior
- Accession number :
- edsair.doi.dedup.....f8e673ff8929b49c4220248e58d0caa1
- Full Text :
- https://doi.org/10.1016/j.pbb.2010.11.012