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Time Course for Effects of Hypoglycemia on Insulin Gene Transcription In Vivo
- Source :
- Diabetes. 43:929-934
- Publication Year :
- 1994
- Publisher :
- American Diabetes Association, 1994.
-
Abstract
- The purpose of these studies was to determine the time course for onset of effects of hypoglycemia on insulin gene transcription in vivo. Using insulin infusions, we found that insulin-induced hypoglycemia decreased levels of precursors for insulin mRNA, reflecting changes in new mRNA synthesis, to new steady-state values within 100 min. These changes were followed by declines in processed insulin mRNA. An alternate infusion technique was developed to lower plasma glucose levels from a constant level of 120–130 to 50–60 mg/dl in
- Subjects :
- Blood Glucose
medicine.medical_specialty
Time Factors
Transcription, Genetic
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Gene Expression
Biology
Hypoglycemia
In vivo
Transcription (biology)
Internal medicine
Gene expression
RNA Precursors
Internal Medicine
medicine
Animals
Insulin
RNA, Messenger
Pancreatic hormone
Messenger RNA
medicine.disease
Rats
Insulin oscillation
Kinetics
Endocrinology
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....f8e0f068a52b6f2feaacd4c5f79a128f