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Comparative safety analysis of bactericidal nano-colloids: Assessment of potential functional toxicity and radical scavenging action
- Source :
- Colloids and Surfaces B: Biointerfaces. 184:110508
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Extensive utilization of silver nanoparticles (AgNP) has raised concerns of their safety profile upon interaction with biological system. In past decade, various nanoparticles (NPs) with excellent antimicrobial potential have been synthesized, a majority of which have struggled with the established toxicity in biological systems. The NPs safety is still a hot debate and various strategies are being adopted to overcome this giant limitation. This paper successfully reports comparative toxicity profiles of previously synthesized antimicrobial NPs in our lab and concludes the effectiveness of biologically synthesized NPs for its safe usage in biological systems. In this study, five of our previously synthesized NPs that showed excellent antimicrobial potential were compared for their in vivo toxicity and corresponding radical scavenging activities. Based on lowest morbidity, mortality, weight loss, toxicity and agglomeration profile, best NPs with highest antimicrobial potentials were screened out and used for further biomedical applications. The previously reported NPs used in this study included Aerva javanica synthesized nanoparticles (AjNPs), Heliotropium crispium synthesized nanoparticles (HcNPs), and violacein capped nanoparticles (VNPs), these showed least toxicity upon in vivo histological analysis. AjNPs among them showed maximum safety and efficacy profile and consistently showed least production of reactive oxygen species, least mortality and morbidity rate as compared to other groups. Present study establishes that all these biologically synthesized NPs and specifically AjNPs can be efficiently employed as antimicrobial agents as they have not exhibited toxic profile and have shown least accumulation into the organs such as liver spleen and kidney.
- Subjects :
- Silver
Surface Properties
Metal Nanoparticles
Nanoparticle
02 engineering and technology
In vivo toxicity
Kidney
01 natural sciences
Silver nanoparticle
Mice
Colloid
Colloid and Surface Chemistry
In vivo
0103 physical sciences
Animals
Colloids
Particle Size
Physical and Theoretical Chemistry
chemistry.chemical_classification
Mice, Inbred BALB C
Reactive oxygen species
010304 chemical physics
Free Radical Scavengers
Surfaces and Interfaces
General Medicine
021001 nanoscience & nanotechnology
Antimicrobial
Combinatorial chemistry
Anti-Bacterial Agents
Liver
chemistry
Toxicity
0210 nano-technology
Spleen
Biotechnology
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 184
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....f8df1c4d3a44256c67b8e9295bd3d276