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Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients
Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients
- Source :
- Upsala Journal of Medical Sciences
- Publication Year :
- 2010
- Publisher :
- Uppsala Medical Society, 2010.
-
Abstract
- Objective Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, is amplified and over-expressed in various cancers. The objective of the present study was to investigate the concentration of DcR3 in sera of hepatocellular carcinoma (HCC) patients and its clinical significance. Methods Serum concentrations of DcR3 were measured by enzyme-linked immunosorbent assay (ELISA) in 67 patients with HCC, 8 with liver cirrhosis, 17 with cholecystitis, and in 28 healthy individuals. Immunohistochemistry was employed to access protein expression of DcR3 in the corresponding HCC tissues. Results Serum concentrations of DcR3 in patients with HCC or cirrhosis were significantly higher than in healthy individuals (P < 0.01). Moreover, serum concentrations of DcR3 in HCC patients were associated with TNM stage, para-cirrhosis, capsular infiltration, and metastasis or recurrence of disease (P < 0.05). There was a positive correlation between the serum concentration of DcR3 and protein expression in HCC tissues (r = 0.472, P < 0.01). Conclusions The high serum concentration of DcR3 might play a certain role in pathogenesis, progress, and metastasis of HCC. Moreover, DcR3 might serve as a valuable molecular indicator in early diagnosis and contribute to predicting the clinical outcome in HCC patients.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Cirrhosis
Enzyme-Linked Immunosorbent Assay
Metastasis
hepatocellular carcinoma (HCC)
Recurrence
Biomarkers, Tumor
Cholecystitis
medicine
Carcinoma
Humans
Clinical significance
enzyme-linked immunosorbent assay (ELISA)
Neoplasm Metastasis
Receptor
Aged
business.industry
Liver Neoplasms
Receptors, Tumor Necrosis Factor, Member 6b
General Medicine
Middle Aged
medicine.disease
digestive system diseases
immunohistochemistry (IHC)
Gene Expression Regulation, Neoplastic
Decoy receptor 3 (DcR3)
Hepatocellular carcinoma
Immunohistochemistry
Female
Original Article
Decoy receptor 3
business
Subjects
Details
- ISSN :
- 20001967 and 03009734
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Upsala Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....f8cee656d2436fc376403bc8fdb42d8e
- Full Text :
- https://doi.org/10.3109/03009734.2010.516410