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Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients

Significance of decoy receptor 3 in sera of hepatocellular carcinoma patients

Authors :
Gang Chen
Meisongzhu Yang
Yi-Wu Dang
Dian-Zhong Luo
Source :
Upsala Journal of Medical Sciences
Publication Year :
2010
Publisher :
Uppsala Medical Society, 2010.

Abstract

Objective Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, is amplified and over-expressed in various cancers. The objective of the present study was to investigate the concentration of DcR3 in sera of hepatocellular carcinoma (HCC) patients and its clinical significance. Methods Serum concentrations of DcR3 were measured by enzyme-linked immunosorbent assay (ELISA) in 67 patients with HCC, 8 with liver cirrhosis, 17 with cholecystitis, and in 28 healthy individuals. Immunohistochemistry was employed to access protein expression of DcR3 in the corresponding HCC tissues. Results Serum concentrations of DcR3 in patients with HCC or cirrhosis were significantly higher than in healthy individuals (P < 0.01). Moreover, serum concentrations of DcR3 in HCC patients were associated with TNM stage, para-cirrhosis, capsular infiltration, and metastasis or recurrence of disease (P < 0.05). There was a positive correlation between the serum concentration of DcR3 and protein expression in HCC tissues (r = 0.472, P < 0.01). Conclusions The high serum concentration of DcR3 might play a certain role in pathogenesis, progress, and metastasis of HCC. Moreover, DcR3 might serve as a valuable molecular indicator in early diagnosis and contribute to predicting the clinical outcome in HCC patients.

Details

ISSN :
20001967 and 03009734
Volume :
115
Database :
OpenAIRE
Journal :
Upsala Journal of Medical Sciences
Accession number :
edsair.doi.dedup.....f8cee656d2436fc376403bc8fdb42d8e
Full Text :
https://doi.org/10.3109/03009734.2010.516410