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A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn
- Source :
- Journal of ethnopharmacology. 149(2)
- Publication Year :
- 2013
-
Abstract
- Ethnopharmacological relevance Polygonum chinense Linn., a folk medicine, has long been used for the treatment of diarrhea and enteritis in southwestern China. However, the components responsible for its anti-diarrheal activity are still poorly understood. Aim of the study To determine anti-diarrheal activities of Polygonum chinense L. and to identify its active components through bioactivity-guided isolation technique. Materials and methods Animals were orally administered with the extract of Polygonum chinense L. The anti-diarrheal effects of 75% ethanol extract, four fractions with different polarities from 75% ethanol extract, different eluates collected from Diaion HP-20 macroporous resin chromatography, ellagic acid and corilagin, were examined based on mouse models of castor oil- and magnesium sulfate-induced diarrhea. Results The results showed that the 75% ethanol extract of Polygonum chinense L. exhibited significant anti-diarrheal activities in a dose-dependent manner in two mouse models. Through in vivo bioactivity-guided fractionation processes, n -butanol and aqueous fractions were found to exhibit prominent anti-diarrheal activities, and two major compounds, ellagic acid and corilagin, from these active fractions were found to possess anti-diarrheal effects. Conclusion Present study provides evidence of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect.
- Subjects :
- Diarrhea
Polygonum
Castor Oil
Fractionation
Chemical Fractionation
High-performance liquid chromatography
chemistry.chemical_compound
Magnesium Sulfate
Mice
Ellagic Acid
Glucosides
Drug Discovery
medicine
Animals
Antidiarrheals
Pharmacology
Mice, Inbred ICR
Traditional medicine
biology
Chemistry
Plant Extracts
Plant Components, Aerial
biology.organism_classification
Thin-layer chromatography
Hydrolyzable Tannins
Polygonum chinense
Castor oil
Solvents
Corilagin
medicine.drug
Ellagic acid
Phytotherapy
Subjects
Details
- ISSN :
- 18727573
- Volume :
- 149
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of ethnopharmacology
- Accession number :
- edsair.doi.dedup.....f8ce93f3b7bb4cbed56212ca5a8c5a6c