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Comment on 'PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia'
- Source :
- Sci Transl Med
- Publication Year :
- 2019
-
Abstract
- LB100 sensitizes resistant chronic phase CML stem and progenitor cells to TKIs and spares healthy bone marrow cells.
- Subjects :
- Human leukemia
business.industry
Fusion Proteins, bcr-abl
Apoptosis
ABL Tyrosine Kinase
General Medicine
Drug resistance
Protein phosphatase 2
medicine.disease
Fusion protein
Article
Myelogenous
Leukemia
Cancer stem cell
Drug Resistance, Neoplasm
hemic and lymphatic diseases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cancer research
Neoplastic Stem Cells
Medicine
Humans
business
neoplasms
Protein Kinase Inhibitors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Sci Transl Med
- Accession number :
- edsair.doi.dedup.....f8ca30496d24e5a11493b37bfdb09433