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Atrial Fibrillation: A New Indicator for Advanced Colorectal Neoplasia in Screening Colonoscopy

Authors :
Elmar Aigner
David Niederseer
Peter C. Kahr
Slayman Obeid
Christian Schmied
Sabrina Hammerl
Laurent M. Haegeli
Ursula Huber-Schönauer
Sebastian Bachmayer
Sarah Eder
Christian Datz
University of Zurich
Source :
Journal of Clinical Medicine, Volume 8, Issue 7, Journal of Clinical Medicine, Vol 8, Iss 7, p 1083 (2019)
Publication Year :
2019
Publisher :
MDPI AG, 2019.

Abstract

Background: Colorectal cancer (CRC) is a common and potentially preventable malignancy. Evidence has emerged that coronary artery disease patients are at increased risk for developing CRC by shared risk factors. Here we investigated an association between CRC and atrial fibrillation (AF), a surrogate marker of cardiovascular risk, in the setting of routine screening colonoscopy. Methods: We investigated 1949 asymptomatic participants (median age 61 [54&ndash<br />67] years, 49% females) undergoing screening colonoscopy within the SAKKOPI registry (Salzburg Colon Cancer Prevention Initiative). Forty-six participants with AF (2.4%) were identified, and colonoscopy findings were compared to non-AF participants. Propensity Score Matching (PSM) was used to create 1:1 and 3:1 age- and gender-matched couples. Results: Abnormal findings on screening colonoscopy (any form of adenoma or carcinoma) were more common in AF participants with an odds ratios (OR) of 2.4 [1.3&ndash<br />4.3] in the unmatched analysis, and 2.6 [1.1&ndash<br />6.3] and 2.0 [1.1&ndash<br />4.0] in the 1:1 and 3:1 matched groups, respectively. Correspondingly, the odds of finding advanced adenomas or carcinomas was elevated about three-fold across the different matched and unmatched analyses (OR 3.3 [1.1&ndash<br />10.8] for 3:1 matched participants). At the same time, the prevalence and number of colonic lesions were significantly higher in AF participants (63.0% vs. 33.4% for 3:1 matched participants, p &lt<br />0.001). Non-CRC related findings on colonoscopy, like diverticulosis, were non-different between groups. Conclusion: Participants with AF had a higher burden of advanced premalignant adenomas and CRC in routine colonoscopy screening. Our data suggest that practitioners should monitor the CRC screening status, especially in AF patients.

Details

ISSN :
20770383
Volume :
8
Database :
OpenAIRE
Journal :
Journal of Clinical Medicine
Accession number :
edsair.doi.dedup.....f8b441408966754d94c294e9ebaf1b77
Full Text :
https://doi.org/10.3390/jcm8071083