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Should we reconsider lung transplantation through uncontrolled donation after circulatory death?
- Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 14(4)
- Publication Year :
- 2013
-
Abstract
- Lung transplantation through controlled donation after circulatory death (cDCD) has slowly gained universal acceptance with reports of equivalent outcomes to those through donation after brain death. In contrast, uncontrolled DCD (uDCD) lung use is controversial and requires ethical, legal and medical complexities to be addressed in a limited time. Consequently, uDCD lung use has not previously been reported in the United States. Despite these potential barriers, we present a case of a patient with multiple gunshot wounds to the head and the body who was unsuccessfully resuscitated and ultimately became an uDCD donor. A cytomegalovirus positive recipient who had previously consented for CDC high-risk, DCD and participation in the NOVEL trial was transplanted from this uDCD donor, following 3 hours of ex vivo lung perfusion. The postoperative course was uneventful and the recipient was discharged home on day 9. While this case represents a “best-case scenario,” it illustrates a method for potential expansion of the lung allograft pool through uDCD after unsuccessful resuscitation in hospitalized patients.
- Subjects :
- Adult
Male
Resuscitation
medicine.medical_specialty
Tissue and Organ Procurement
medicine.medical_treatment
Article
Donor Selection
Intensive care
medicine
Immunology and Allergy
Lung transplantation
Humans
Pharmacology (medical)
Intensive care medicine
Transplantation
Lung
Donor selection
business.industry
Ex vivo lung perfusion
Graft Survival
Prognosis
Circulatory death
Tissue Donors
Death
medicine.anatomical_structure
Donation
business
Lung Transplantation
Subjects
Details
- ISSN :
- 16006143
- Volume :
- 14
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Accession number :
- edsair.doi.dedup.....f8aed4471c1587fd52b3b9a02c94b4c9