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Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia
- Source :
- Journal of colloid and interface science, 579 (2020): 186–194. doi:10.1016/j.jcis.2020.05.119, info:cnr-pdr/source/autori:Das P.; Salvioni L.; Malatesta M.; Vurro F.; Mannucci S.; Gerosa M.; Antonietta Rizzuto M.; Tullio C.; Degrassi A.; Colombo M.; Ferretti A.M.; Ponti A.; Calderan L.; Prosperi D./titolo:Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia/doi:10.1016%2Fj.jcis.2020.05.119/rivista:Journal of colloid and interface science (Print)/anno:2020/pagina_da:186/pagina_a:194/intervallo_pagine:186–194/volume:579
- Publication Year :
- 2020
- Publisher :
- Academic Press Inc., 2020.
-
Abstract
- Colloidally stable nanoparticles-based magnetic agents endowed with very high relaxivity and specific absorption rate are extremely desirable for efficient magnetic resonance imaging and magnetic hyperthermia, respectively. Here, we report a water dispersible magnetic agent consisting of zinc-doped superparamagnetic iron oxide nanoparticles (i.e., Zn-SPIONs) of 15 nm size with high saturation magnetization coated with an amphiphilic polymer for effective magnetic resonance imaging and magnetic hyperthermia of glioblastoma cells. These biocompatible polymer-coated Zn-SPIONs had 24 nm hydrodynamic diameter and exhibited high colloidal stability in various aqueous media, very high transverse relaxivity of 471 mM−1 s−1, and specific absorption rate up to 743.8 W g−1, which perform better than most iron oxide nanoparticles reported in the literature, including commercially available agents. Therefore, using these polymer-coated Zn-SPIONs even at low concentrations, T2-weighted magnetic resonance imaging and moderate magnetic hyperthermia of glioblastoma cells under clinically relevant magnetic field were successfully implemented. In addition, the results of this in vitro study suggest the superior potential of Zn-SPIONs as a theranostic nanosystem for brain cancer treatment, simultaneously acting as a contrast agent for magnetic resonance imaging and a heat mediator for localized magnetic hyperthermia.
- Subjects :
- Materials science
Polymers
Zinc doping
Nanoparticle
Contrast Media
02 engineering and technology
010402 general chemistry
High relaxivity
01 natural sciences
Biomaterials
Colloid
chemistry.chemical_compound
Colloid and Surface Chemistry
Nuclear magnetic resonance
medicine
Humans
Hyperthermia
Magnetite Nanoparticles
chemistry.chemical_classification
medicine.diagnostic_test
Superparamagnetism
Magnetic resonance imaging
Polymer
Polymer coating
021001 nanoscience & nanotechnology
equipment and supplies
Magnetic Resonance Imaging
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Magnetic field
Zinc
Magnetic hyperthermia
chemistry
Iron oxide nanoparticle
Nanoparticles
Magnetic Iron Oxide Nanoparticles
Cancer theranostic
0210 nano-technology
High specific absorption rate
human activities
Iron oxide nanoparticles
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of colloid and interface science, 579 (2020): 186–194. doi:10.1016/j.jcis.2020.05.119, info:cnr-pdr/source/autori:Das P.; Salvioni L.; Malatesta M.; Vurro F.; Mannucci S.; Gerosa M.; Antonietta Rizzuto M.; Tullio C.; Degrassi A.; Colombo M.; Ferretti A.M.; Ponti A.; Calderan L.; Prosperi D./titolo:Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia/doi:10.1016%2Fj.jcis.2020.05.119/rivista:Journal of colloid and interface science (Print)/anno:2020/pagina_da:186/pagina_a:194/intervallo_pagine:186–194/volume:579
- Accession number :
- edsair.doi.dedup.....f894af647bd546f2c7d52768c68928a7