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Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle
- Source :
- International Neurourology Journal, Vol 25, Iss Suppl 2, Pp S47-54 (2021), International Neurourology Journal
- Publication Year :
- 2021
- Publisher :
- Korean Continence Society, 2021.
-
Abstract
- Purpose: The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated.Methods: Female Sprague-Dawley rats were divided into control (CON), ovariectomy (OVX), and ovariectomy plus exercise (OVX+EX) groups. After ovarian excision, exercise training was performed using a rat treadmill at 20 m/min, 50 min/day, 5 days/week for 12 weeks. Protein levels of mitochondria-mediated apoptotic signaling and atrophy/hypertrophy signaling in the skeletal muscle (soleus) were examined through western immunoblot analysis.Results: The number of myocytes and myocyte cross-sectional area (CSA) were increased and the extramyocyte space was decreased in the OVX group compared to those in the CON group. However, aerobic exercise training significantly increased myocyte CSA and decreased extramyocyte space in the OVX+EX group compared to those in the OVX group. The protein levels of proapoptotic signaling and muscle atrophy signaling were significantly increased, whereas the protein levels of muscle hypertrophy signaling were significantly decreased in the OVX group compared to that in the CON group. Aerobic exercise training significantly decreased the protein levels of proapoptotic signaling and increased the protein level of antiapoptotic protein in the OVX+EX group compared to that in the OVX group. Aerobic exercise training significantly increased the protein levels of hypertrophy signaling and decreased protein levels of atrophy signaling in the OVX+EX group compared to those in the OVX group.Conclusions: Treadmill exercise improved estrogen deficiency-induced impairment in skeletal muscle remodeling, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in skeletal muscle.
- Subjects :
- medicine.medical_specialty
Urology
Muscle hypertrophy
sarcopenia
Atrophy
Internal medicine
medicine
estrogen
Myocyte
Aerobic exercise
skeletal muscle
Soleus muscle
exercise
business.industry
Skeletal muscle
medicine.disease
Muscle atrophy
Diseases of the genitourinary system. Urology
Endocrinology
medicine.anatomical_structure
ovariectomy
Neurology
Ovariectomized rat
Original Article
Neurology (clinical)
RC870-923
medicine.symptom
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- Language :
- English
- ISSN :
- 20936931 and 20934777
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- International Neurourology Journal
- Accession number :
- edsair.doi.dedup.....f890ee600d80deb014381110d7603075