Back to Search
Start Over
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
- Publication Year :
- 2021
- Publisher :
- Umeå universitet, Klinisk kemi, 2021.
-
Abstract
- Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was − 0.91 standard-deviations lower in women than men (95%CI − 0.98; − 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p
- Subjects :
- Male
0301 basic medicine
Epidemiology
Science
medicine.medical_treatment
Population
Physiology
Renal function
Kidney
Article
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
education
Kynurenine
Aged
Aged, 80 and over
Inflammation
Creatinine
education.field_of_study
Cancer och onkologi
Multidisciplinary
business.industry
Smoking
Vitamins
Middle Aged
Carbon
B vitamins
C-Reactive Protein
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Cancer and Oncology
Cohort
Medicine
Smoking cessation
Biomarker (medicine)
Female
Smoking Cessation
business
Body mass index
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
- Accession number :
- edsair.doi.dedup.....f88e5ec64851b7b23a7e47bb7a5b3207