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Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow
- Source :
- PLoS ONE, Vol 11, Iss 9, p e0161563 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Substance P is released in painful and inflammatory conditions, affecting both peripheral processes and the central nervous system neurokinin 1 (NK1) receptor. There is a paucity of data on human brain alterations in NK1 expression, how this system may be affected by treatment, and interactions between central and peripheral tissue alterations. Ten subjects with chronic tennis elbow (lateral epicondylosis) were selected out of a larger (n = 120) randomized controlled trial evaluating graded exercise as a treatment for chronic tennis elbow (lateral epicondylosis). These ten subjects were examined by positron emission tomography (PET) with the NK1-specific radioligand 11C-GR205171 before, and eight patients were followed up after treatment with graded exercise. Brain binding in the ten patients before treatment, reflecting NK1-receptor availability (NK1-RA), was compared to that of 18 healthy subjects and, longitudinally, to the eight of the original ten patients that agreed to a second PET examination after treatment. Before treatment, patients had significantly lower NK1-RA in the insula, vmPFC, postcentral gyrus, anterior cingulate, caudate, putamen, amygdala and the midbrain but not the thalamus and cerebellum, with the largest difference in the insula contralateral to the injured elbow. No significant correlations between brain NK1-RA and pain, functional severity, or peripheral NK1-RA in the affected limb were observed. In the eight patients examined after treatment, pain ratings decreased in everyone, but there were no significant changes in NK1-RA. These findings indicate a role for the substance P (SP) / NK1 receptor system in musculoskeletal pain and tissue healing. As neither clinical parameters nor successful treatment response was reflected in brain NK1-RA after treatment, this may reflect the diverse function of the SP/NK1 system in CNS and peripheral tissue, or a change too small or slow to capture over the three-month treatment.
- Subjects :
- Central Nervous System
0301 basic medicine
myalgia
Pathology
Sensory Receptors
Neurology
Neurologi
Social Sciences
lcsh:Medicine
Substance P
Pathology and Laboratory Medicine
Nervous System
Diagnostic Radiology
chemistry.chemical_compound
0302 clinical medicine
Cerebellum
Elbow
Medicine and Health Sciences
Psychology
lcsh:Science
Musculoskeletal System
Tomography
Immune Response
Cerebral Cortex
Multidisciplinary
Radiology and Imaging
Putamen
Brain
Human brain
Arms
medicine.anatomical_structure
Anesthesia
Sensory Perception
Anatomy
medicine.symptom
Research Article
Signal Transduction
Radiology, Nuclear Medicine and Medical Imaging
medicine.medical_specialty
Drug Research and Development
Imaging Techniques
Immunology
Central nervous system
Neuroimaging
Research and Analysis Methods
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
medicine
Tennis elbow
Pain Management
Clinical Trials
Inflammation
Pharmacology
Postcentral gyrus
business.industry
Limbs (Anatomy)
lcsh:R
Biology and Life Sciences
Myalgia
Cell Biology
medicine.disease
Randomized Controlled Trials
030104 developmental biology
chemistry
lcsh:Q
Radiologi och bildbehandling
Clinical Medicine
business
Positron Emission Tomography
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....f87bb561606263eefb1cde4a943b5349