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Outcomes of conception subsequent to methotrexate treatment for an unruptured ectopic pregnancy
- Source :
- International Journal of Gynecology & Obstetrics. 139:170-173
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objective To assess the risk of adverse pregnancy outcomes in subsequent pregnancies among women treated with methotrexate for ectopic pregnancy. Methods In a retrospective single-center study, data were assessed for women treated with methotrexate for ectopic pregnancy at Asaf Harofe Medical Center, Zerifin, Israel, between May 2004 and May 2014. Results Overall, 226 women were treated with methotrexate for ectopic pregnancy and subsequently conceived. The median time from treatment to conception was 10 months (range 1–120 months), and 127 women conceived within 12 months of treatment. Except for early missed abortion—which affected 23 (10.2%) pregnancies—adverse pregnancy outcomes such as fetal malformations were rare. The frequency of early abortion was lowest for women who conceived within 6 months of treatment with methotrexate (3/93, 3.2%), increased between 6 and 23 months (15/83, 18.1%), and remained high thereafter (7/50, 14.0%; P=0.006). Conclusion The frequency of fetal malformation in a subsequent pregnancy was low among women treated with methotrexate for ectopic pregnancy. The frequency of early missed abortion was lowest during the first 6 months after treatment with methotrexate. This article is protected by copyright. All rights reserved.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
030105 genetics & heredity
Young Adult
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
Israel
Young adult
Retrospective Studies
Methotrexate treatment
Gynecology
Missed abortion
Abortifacient Agents, Nonsteroidal
Fetus
030219 obstetrics & reproductive medicine
Ectopic pregnancy
Obstetrics
business.industry
Pregnancy Outcome
Obstetrics and Gynecology
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Pregnancy, Ectopic
Methotrexate
Female
Abortion, Missed
business
medicine.drug
Subjects
Details
- ISSN :
- 00207292
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecology & Obstetrics
- Accession number :
- edsair.doi.dedup.....f87a2724601985a61d1dd2714191e325