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Salmonella genomic island 1-J variants associated with change in the antibiotic resistance gene cluster in multidrug-resistant Salmonella enterica serovar Virchow isolated from humans, Taiwan, 2004–2006
- Source :
- Clinical Microbiology and Infection, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2012, 18 (1), pp.47-53. ⟨10.1111/j.1469-0691.2011.03464.x⟩
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- International audience; Salmonella genomic island I (variant SGII-J3) has been previously identified in multi-drug resistant (MDR) Salmonella enterica serovar Virchow isolated from humans in 1994. In this study, antimicrobial resistance, genotypes and genetic relationship were investigated in 96 S. Virchow isolates collected from humans in 2004-2006. XbaI-PFGE analysis separated 96 isolates into two main related-clusters, I and II, which consisted of four major pulsotypes differing in prevalence by year. The majority of isolates were MDR to chloramphenicol, sulfonamide, trimethoprim and tetracyclines associated with antimicrobial resistance genes dfrA1, floR2, sull and tet(G) of variant SGII-J3. Among nine variants, we determined two novel variants SGII-J4 and -J5, which have undergone different homologous recombinational events resulting in partial deletions of the MDR region. The first one contained an empty integron structure and the second presented a deletion extending from the IS6100 element to the adjacent SGII backbone. SGII-J3 is largely encountered in clonally related MDR S. Virchow isolates collected from humans which spread vertically. The genomic island SGII appears to be largely responsible for the diversity of MDR phenotypes among S. Virchow isolates in Taiwan.
- Subjects :
- DNA, Bacterial
Microbiology (medical)
Salmonella
Genomic Islands
Genotype
PFGE analysis
Taiwan
Microbial Sensitivity Tests
Drug resistance
Integron
medicine.disease_cause
Microbiology
03 medical and health sciences
Antibiotic resistance
Salmonella genomic island
Drug Resistance, Multiple, Bacterial
Genomic island
plasmid
medicine
Humans
antimicrobial resistance
Sequence Deletion
030304 developmental biology
Genetics
0303 health sciences
biology
030306 microbiology
Salmonella enterica
General Medicine
biology.organism_classification
bacterial infections and mycoses
S. virchow
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
3. Good health
Multiple drug resistance
Infectious Diseases
Multigene Family
Salmonella Infections
biology.protein
Genes, MDR
Subjects
Details
- ISSN :
- 1198743X and 14690691
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection
- Accession number :
- edsair.doi.dedup.....f86a7b60c6030cf18f35325b05429a52
- Full Text :
- https://doi.org/10.1111/j.1469-0691.2011.03464.x