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Cooking methods employing natural anti-oxidant food additives effectively reduced concentration of nephrotoxic and carcinogenic aristolochic acids in contaminated food grains
- Source :
- Food Chemistry. 264:270-276
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Emerging evidence suggests that aristolochic acids (AA) produced naturally by a common weed Aristolochia clematitis in the cultivation fields is contaminating the food products in Balkan Peninsula and acting as the etiological agent in the development of Balkan endemic nephropathy. In this study, we investigated the combined use of natural anti-oxidative "food additives" and different cooking methods to find a solution for the widespread contamination of AA in food products. The results indicated that the addition of healthy dietary supplements (such as cysteine, glutathione, ascorbic acid, citric acid and magnesium) during cooking, is a highly efficient method in lowering the concentration of AA in the final food products. Because previous observation indicated one of the toxicological mechanisms by which AA exert its toxicity is to induce oxidative stress in internal organs, it is anticipated that these added anti-oxidants will also help to attenuate the nephrotoxicity of AA.
- Subjects :
- 0301 basic medicine
food.ingredient
Balkan Nephropathy
Flour
Aristolochic acid
Food Contamination
Ascorbic Acid
Antioxidants
Citric Acid
Analytical Chemistry
03 medical and health sciences
chemistry.chemical_compound
food
medicine
Humans
Magnesium
Cooking
Cysteine
Food science
Carcinogen
Food poisoning
biology
Food additive
Aristolochia clematitis
General Medicine
Glutathione
Aristolochia
biology.organism_classification
Ascorbic acid
medicine.disease
030104 developmental biology
chemistry
Dietary Supplements
Carcinogens
Aristolochic Acids
Food Additives
Citric acid
Food Science
Subjects
Details
- ISSN :
- 03088146
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Food Chemistry
- Accession number :
- edsair.doi.dedup.....f8684af6ed20d98050dab712a18a8ef4