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Associations of Interleukin-5 With Plaque Development and Cardiovascular Events
- Source :
- JACC: Basic to Translational Science, JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 891-902 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Visual Abstract<br />Highlights • There is strong experimental evidence that IL-5 has a protective role in atherosclerosis but the clinical importance of this remains poorly studied. • In a prospective study involving 696 subjects with a follow-up of close to 17 years we show that baseline plasma levels of IL-5 do not predict risk for coronary events and stroke. • However, subjects with high levels of IL-5 were less likely to have a carotid plaque at the baseline investigation. • Experimental studies using a shear stress-modifying cast to the carotid artery of Apoe−/− mice deficient for IL-5 showed that lack of IL-5 was associated with increased plaque formation at sites of oscillatory blood flow. • The findings are in line with previous experimental observations of an atheroprotective role of IL-5 but do not support the use of IL-5 measurement in cardiovascular risk prediction.<br />Summary Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in Apoe−/− mice suggesting a protective role for IL-5 in plaque development.
- Subjects :
- 0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
MACE, major adverse cardiac events
Carotid arteries
interleukin 5
IL-5, interleukin-5
030204 cardiovascular system & hematology
CVD, cardiovascular disease
03 medical and health sciences
PRECLINICAL RESEARCH
0302 clinical medicine
Internal medicine
medicine
Myocardial infarction
Prospective cohort study
Interleukin 5
Stroke
ApoE, apolipoprotein E
business.industry
Plasma levels
medicine.disease
stroke
HR, hazard ratio
3. Good health
Acute cardiovascular disease
Oscillatory blood flow
OR, odds ratio
030104 developmental biology
myocardial infarction
ILC2, type 2 innate lymphoid cells
lcsh:RC666-701
Cardiology
atherosclerosis
Cardiology and Cardiovascular Medicine
business
Editorial Comment
Subjects
Details
- Language :
- English
- ISSN :
- 2452302X
- Volume :
- 4
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- JACC: Basic to Translational Science
- Accession number :
- edsair.doi.dedup.....f8591ebbf3d074225b9de87f67474343