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Gonadal function after combination chemotherapy for Hodgkin's disease in childhood
- Source :
- Archives of Disease in Childhood. 57:287-291
- Publication Year :
- 1982
- Publisher :
- BMJ, 1982.
-
Abstract
- The effect of quadruple chemotherapy (mustine, vincristine, procarbazine, and prednisolone) on gonadal function was investigated in 15 males and 2 females treated for Hodgkin's disease during childhood. The 2 females have regular menstrual cycles with evidence of ovulation in one. Twelve of the males have shown normal progression of pubertal development since completing their treatment. Nine out of 10 late pubertal or adult subjects had small testes but only one developed gynaecomastia. All 4 prepubertal subjects had normal basal and peak gonadotrophin responses to luteinising hormone-releasing hormone. Nine of the 12 subjects studied during puberty or adulthood had either an increased basal serum follicle-stimulating hormone (FSH) level or an exaggerated FSH response to luteinising hormone-releasing hormone. Each of the 6 males who provided semen for analysis was azoospermic after an interval of between 2.4 and 8 (mean 5.3) years after completion of treatment. We conclude that severe testicular damage is common after treatment with mustine, vincristine, procarbazine, and prednisolone in childhood. The germinal epithelium is particularly vulnerable and the resultant azoospermia is likely to be irreversible. The Leydig cells are less susceptible to cytotoxic-induced damage. Pubertal development is normal and there is no indication for androgen replacement therapy.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Vincristine
Adolescent
Prednisolone
media_common.quotation_subject
medicine.medical_treatment
Antineoplastic Agents
Procarbazine
Testicular Diseases
Internal medicine
medicine
Humans
Mechlorethamine
Ovarian Diseases
Child
Ovulation
media_common
Azoospermia
business.industry
Puberty
Combination chemotherapy
Oligospermia
medicine.disease
Hodgkin Disease
Endocrinology
Child, Preschool
Pediatrics, Perinatology and Child Health
Drug Therapy, Combination
Female
Androgen replacement therapy
business
Research Article
Hormone
medicine.drug
Subjects
Details
- ISSN :
- 14682044 and 00039888
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Archives of Disease in Childhood
- Accession number :
- edsair.doi.dedup.....f852ade0d8953ba27a2659ca9c9018b5