Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis

We conducted a case-control study to assess the relation- ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to have drinking and smoking habits and have lower bone mineral density in the L 2 -L 4 vertebrae, femoral neck, and total hip. According to conditional regression analysis, individuals carrying the TT genotype of rs35767 had an increased risk of osteoporosis, with an adjusted odds ratio (95% confidence interval) of 2.29 (1.35-4.97). In conclusion, our results sug - gest that the TT genotype of IGF-I rs35767 was associated with an in- creased risk of osteoporosis, suggesting that this polymorphism can be used as a predictive factor for osteoporosis risk.