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Limitations of preoperative cytology for medullary thyroid cancer: Proposal for improved preoperative diagnosis for optimal initial medullary thyroid carcinoma specific surgery
- Source :
- Head & Neck. 43:920-927
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background Preoperative diagnosis of medullary thyroid carcinoma (MTC) is often difficult, given the poor sensitivity of fine-needle aspiration (FNA) cytology for MTC. This study investigates this issue and presents recommendations for improving preoperative diagnostic paradigms in MTC cases. Design/method Histopathologically confirmed MTC patients with preoperative cytologic assessment of index nodules were enrolled. FNA diagnosis, final pathology, and surgery details were collected. Results Out of 71 patients, 49 (69%) were diagnosed by FNA as either definitive MTC (35, 49%) or suspected MTC (14, 20%) and 22 (31%) patients had no indication of MTC on FNA. Conclusion In a tertiary-care setting, one-third of subjects had an FNA interpretation that did not suggest the possibility of MTC. The limitations of preoperative diagnosis are especially problematic for MTC as they can cause delayed or incomplete treatment. Additional testing is proposed to improve preoperative diagnosis and surgical care of MTC patients.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
Medullary cavity
Cytodiagnosis
Biopsy, Fine-Needle
030209 endocrinology & metabolism
Thyroid carcinoma
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Cytology
medicine
Humans
Thyroid Neoplasms
Thyroid Nodule
business.industry
Surgical care
Medullary thyroid cancer
respiratory system
medicine.disease
digestive system diseases
Carcinoma, Neuroendocrine
Surgery
Otorhinolaryngology
030220 oncology & carcinogenesis
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 10970347 and 10433074
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....f82f2d475a4c27f40b64949d7267f40b