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miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression
- Source :
- Oncology reports. 37(1)
- Publication Year :
- 2016
-
Abstract
- Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal controls. Moreover, overexpression of miR-3619-5p readily induced CDKN1A gene expression by directly targeting the putative site in the promoter. Besides, miR-3619-5p possessed considerable capacity to inhibit prostate cancer DU145 and PC3 cell growth, and downregulate several CDKN1A downstream genes, such as cyclin D1, CDK4 and CDK6. Notably, this antitumor function of miR-3619-5p was mainly achieved by stimulating CDKN1A expression.
- Subjects :
- 0301 basic medicine
Cyclin-Dependent Kinase Inhibitor p21
Male
Cancer Research
RNA activation
Biology
medicine.disease_cause
03 medical and health sciences
DU145
Cell Line, Tumor
microRNA
Gene expression
medicine
Humans
Cyclin D1
Promoter Regions, Genetic
Cell Proliferation
Regulation of gene expression
Cell Cycle
Cyclin-Dependent Kinase 4
Prostatic Neoplasms
General Medicine
Cyclin-Dependent Kinase 6
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
Oncology
Cancer research
biology.protein
Cyclin-dependent kinase 6
Carcinogenesis
A431 cells
Subjects
Details
- ISSN :
- 17912431
- Volume :
- 37
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....f82628584651906ae4c996fcfdcd0059