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Cashew apple (Anacardium occidentale L.) extract from a by-product of juice processing: assessment of its toxicity, antiproliferative and antimicrobial activities
- Source :
- J Food Sci Technol
- Publication Year :
- 2020
- Publisher :
- Springer India, 2020.
-
Abstract
- Cashew apple extract (CAE) is a product with intense yellow color obtained from residual fibers of juice processing. Although CAE is known to be rich in carotenoids and anacardic acids, the biological activities of this potential natural food colorant remain unexplored. The present study is the first to investigate the toxicity, antiproliferative and antimicrobial activities of the lyophilized CAE (L-CAE) and its encapsulated products, using maltodextrin (M-CAE) or cashew gum (CG-CAE) as carriers. In addition to their high carotenoid content, the phenolic contents in all materials was determined using UPLC-QTOF-MS(E). The acute toxicity was performed using adult zebrafish (Danio rerio); antiproliferative activity was assessed using seven different human tumor cell lines [U-251 (glioblastoma), MCF-7 (breast, adenocarcinoma), NCI-ADR/RES (multidrug-resistant ovarian adenocarcinoma), NCI-H-460 (lung, large cell carcinoma), PC-3 (prostate, adenocarcinoma), OVCAR-3 (ovarian adenocarcinoma), and HT-29 (colon, adenocarcinoma)] and an immortalized human keratinocyte (HaCaT) while the antimicrobioal activity was evaluated on Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 19115, Escherichia coli ATCC 25922 and Salmonella Typhimurium ATCC 51812 microorganisms. Both lyophilized and encapsulated CAE samples did not exert acute toxicity against zebrafish neither antiproliferative effect against human tumor and non-tumor cell lines. Further, L-CAE showed potential antimicrobial activity against Listeria monocytogenes, which was confirmed using electron microscopy. The current findings demonstrated that CAE is a potential source of bioactive compounds to use as an additive in the food industry. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13197-020-04594-0) contains supplementary material, which is available to authorized users.
- Subjects :
- biology
Chemistry
Anacardium
04 agricultural and veterinary sciences
biology.organism_classification
Antimicrobial
medicine.disease
medicine.disease_cause
040401 food science
Acute toxicity
Anacardic acids
03 medical and health sciences
HaCaT
chemistry.chemical_compound
0404 agricultural biotechnology
0302 clinical medicine
Listeria monocytogenes
Toxicity
medicine
Adenocarcinoma
Original Article
Food science
030217 neurology & neurosurgery
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Food Sci Technol
- Accession number :
- edsair.doi.dedup.....f81e03f693dbf2a79872cbaeaa26d704