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A tangled tale of microRNA and cardiac fibrosis
- Source :
- Clinical Science. 133:2217-2220
- Publication Year :
- 2019
- Publisher :
- Portland Press Ltd., 2019.
-
Abstract
- Cardiac fibrosis is important for wound healing, regeneration and producing the extracellular matrix (ECM) that provides the scaffold for cells. In pathological situations, fibroblasts are activated and remodel the ECM. In volume 133, issue 17 of Clinical Science, Yang et al. discovered that the miR-214-3p/NLRC5 axis is important for fibroblast-to-myofibroblast transition (FMT) and ECM remodelling in a pressure overload model of fibrosis [Clin. Sci. (2019) 133(17), 1845–1856]. This discovery helps to explain the complicated regulation of cardiac fibrosis. It also underscores the need for more investigation into the mechanisms of cardiac fibrosis to develop better diagnostic modalities and therapeutic options in heart failure.
- Subjects :
- 0301 basic medicine
Pressure overload
Cardiac fibrosis
business.industry
Myocardium
Regeneration (biology)
General Medicine
Fibroblasts
030204 cardiovascular system & hematology
medicine.disease
Bioinformatics
Fibrosis
Extracellular matrix
MicroRNAs
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Heart failure
microRNA
medicine
Humans
Myofibroblasts
business
Wound healing
Subjects
Details
- ISSN :
- 14708736 and 01435221
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Clinical Science
- Accession number :
- edsair.doi.dedup.....f819822ccb51c747b867f277451f5ea3