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Development of a Model of Pediatric Lung Failure Pathophysiology
- Source :
- Repositorio U. El Bosque, Universidad El Bosque, instacron:Universidad El Bosque
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer Health, 2020.
-
Abstract
- A pediatric artificial lung (PAL) is under development as a bridge to transplantation or lung remodeling for children with end-stage lung failure (ESLF). In order to evaluate the efficiency of a PAL, a disease model mimicking the physiologic derangements of pediatric ESLF is needed. Our previous right pulmonary artery ligation (rPA-LM) ovine model achieved that goal, but caused immediate mortality in nearly half of the animals. In this study, we evaluated a new technique of gradual postoperative right pulmonary artery (rPA) occlusion using a Rummel tourniquet (rPA-RT) in seven (25–40 Kg) sheep. This technique created a stable model of ESLF pathophysiology, characterized by high alveolar dead space (58.0±3.8 %), pulmonary hypertension (38.4±2.2 mmHg), tachypnea (79±20 breaths per minute), and intermittent supplemental oxygen requirement. This improvement to our technique provides the necessary physiologic derangements for testing a PAL, while avoiding the problem of high immediate perioperative mortality.
- Subjects :
- medicine.medical_specialty
Biomedical Engineering
Biophysics
Bioengineering
030204 cardiovascular system & hematology
Tachypnea
Artificial lung
Article
Pulmonary hypertension
Biomaterials
03 medical and health sciences
0302 clinical medicine
Internal medicine
Occlusion
medicine
Animals
Humans
Child
Ligation
Lung
Mortalidad del niño
Tourniquet
Sheep
business.industry
General Medicine
Perioperative
medicine.disease
Right pulmonary artery
Prótesis e implantes
Disease Models, Animal
medicine.anatomical_structure
trasplante de pulmón
030228 respiratory system
lung failure
Cardiology
Artificial Organs
medicine.symptom
Animal mode
business
Respiratory Insufficiency
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositorio U. El Bosque, Universidad El Bosque, instacron:Universidad El Bosque
- Accession number :
- edsair.doi.dedup.....f80bb33bab22e423c41f6325f2e122b8