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Efficacy of Crest Herbal Toothpaste in 'Clearing Internal Heat': A Randomized, Double-Blind Clinical Study
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Publishing Corporation, 2013.
-
Abstract
- Objective. Evaluation of the efficacy of Crest Herbal Crystal Toothpaste in “clearing internal heat.” Methods. This was a randomized, double-blind, controlled parallel design clinical test of a product that was already on the market. 72 subjects were randomly assigned to control group (group A with Colgate Herbal Salty Toothpaste) or treatment group (group B with Crest Herbal Crystal Toothpaste) with ratio of 1 : 2. Subjects were instructed to brush with 1g toothpaste for 2 minutes each time, 2 times per day in a 4-aweek test period; measurement with the rating scale on the efficacy of “clearing internal heat” for the herbal toothpaste was done at baseline, 2 weeks, and 4 weeks of toothpaste usage. Results. The rating scale on efficacy of “clearing internal heat” for the herbal toothpaste reveals that the primitive points of 72-case intention-to-treat (ITT) analysis and 67-case per-protocol (PP) analysis for subjects in group A and subjects in group B were found to be reduced progressively with statistical significance ( ). The overall effective rates for group A and group B were, respectively, 62.50%, 56.25% (ITT) and 62.50%, 60.64% (PP). The statistical results indicated that the symptoms of fire-heat for both groups of subjects have been improved after application of toothpaste. Conclusion. The efficacy of Crest Herbal Crystal Toothpaste in “clearing internal heat” was confirmed by the trial as compared to Colgate Herbal Salty Toothpaste. And its efficacy was objectively evaluated by the rating scale on efficacy of “clearing internal heat.”
- Subjects :
- Toothpaste
business.product_category
Article Subject
Traditional medicine
business.industry
Parallel design
Dentistry
lcsh:Other systems of medicine
lcsh:RZ201-999
Double blind
Clinical study
Complementary and alternative medicine
Statistical significance
Medicine
Crest
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- Evidence-based Complementary and Alternative Medicine : eCAM
- Accession number :
- edsair.doi.dedup.....f80b15153953d443f287d021919a17ec